Seroatlas · Human Serome Atlas

GPBAR1

G-protein coupled bile acid receptor 1

Also known as: BG37, GPBAR_HUMAN, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDU6
Gene
GPBAR1
Ensembl
ENSG00000179921
Chromosome
2
Canonical length
330 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q8TDU6|GPBAR1
     1  MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA GCFFLSLLLA
    61  GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL ANLLLVHGER YMAVLRPLQP
   121  PGSIRLALLL TWAGPLLFAS LPALGWNHWT PGANCSSQAI FPAPYLYLEV YGLLLPAVGA
   181  AAFLSVRVLA TAHRQLQDIC RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY
   241  VATLLLSVLA YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ
   301  GLWGRASRDS PGPSIAYHPS SQSSVDLDLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPBAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 30 nTPM
  • breast: 17 nTPM
  • gallbladder: 16 nTPM
  • smooth muscle: 9.5 nTPM
  • spleen: 7.1 nTPM
  • kidney: 6.7 nTPM

Single-cell type

  • decidual stromal cells: 169 nCPM
  • kupffer cells: 61 nCPM
  • neuroendocrine cells: 45 nCPM
  • monocytes: 31 nCPM
  • hofbauer cells: 23 nCPM
  • endometrial stromal cells: 12 nCPM

Immune cell

  • intermediate monocyte: 713 nTPM
  • non-classical monocyte: 699 nTPM
  • classical monocyte: 289 nTPM
  • total PBMC: 156 nTPM
  • myeloid DC: 140 nTPM
  • neutrophil: 6.5 nTPM

Brain region

  • cerebral cortex: 1.8 nTPM
  • cerebellum: 1.2 nTPM
  • thalamus: 1.2 nTPM
  • choroid plexus: 0.9 nTPM
  • basal ganglia: 0.8 nTPM
  • hippocampal formation: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
0.1
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPBAR1 as an antibody target. Whether an autoantibody or antibody against GPBAR1 could matter depends on whether native GPBAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPBAR1 is annotated at the cell surface, where native GPBAR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPBAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPBAR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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