Seroatlas · Human Serome Atlas

GPATCH3

G patch domain-containing protein 3

Also known as: FLJ12455, GPATC3, GPTC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96I76
Gene
GPATCH3
Ensembl
ENSG00000198746
Chromosome
1
Canonical length
525 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and positive regulation of DNA-templated transcription. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q96I76|GPATCH3
     1  MAVPGEAEEE ATVYLVVSGI PSVLRSAHLR SYFSQFREER GGGFLCFHYR HRPERAPPQA
    61  APNSALIPTD PAAEGQLLSQ TSATDVRPLS TRDSTPIQTR TCCCVISVRG LAQAQRLIRM
   121  YSGRRWLDSH GTWLPGRCLI RRLRLPTEAS GLGSFPFKTR KELQSWKAEN EAFTLADLKQ
   181  LPELNPPVLM PRGNVGTPLR VFLELIRACR LPPRIITQLQ LQFPKTGSSR RYGNVPFEYE
   241  DSETVEQEEL VYTAEGEEIP QGTYLADIPA SPCGEPEEEV GKEEEEESHS DEDDDRGEEW
   301  ERHEALHEDV TGQERTTEQL FEEEIELKWE KGGSGLVFYT DAQFWQEEEG DFDEQTADDW
   361  DVDMSVYYDR DGGDKDARDS VQMRLEQRLR DGQEDGSVIE RQVGTFERHT KGIGRKVMER
   421  QGWAEGQGLG CRCSGVPEAL DSDGQHPRCK RGLGYHGEKL QPFGQLKRPR RNGLGLISTI
   481  YDEPLPQDQT ESLLRRQPPT SMKFRTDMAF VRGSSCASDS PSLPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPATCH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 22 nTPM
  • skeletal muscle: 17 nTPM
  • skin: 12 nTPM
  • liver: 12 nTPM
  • tongue: 12 nTPM
  • spleen: 11 nTPM

Single-cell type

  • syncytiotrophoblasts: 44 nCPM
  • differentiating spermatogonia: 31 nCPM
  • retinal ganglion cells: 23 nCPM
  • undifferentiated spermatogonia: 23 nCPM
  • cytotrophoblasts: 21 nCPM
  • cone photoreceptor cells: 21 nCPM

Immune cell

  • basophil: 30 nTPM
  • eosinophil: 22 nTPM
  • non-classical monocyte: 19 nTPM
  • myeloid DC: 19 nTPM
  • classical monocyte: 18 nTPM
  • gdT-cell: 16 nTPM

Brain region

  • white matter: 19 nTPM
  • basal ganglia: 17 nTPM
  • cerebral cortex: 16 nTPM
  • thalamus: 16 nTPM
  • cerebellum: 16 nTPM
  • midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0
gnomAD missense Z
-0.23
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPATCH3 as an antibody target. Whether an autoantibody or antibody against GPATCH3 could matter depends on whether native GPATCH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPATCH3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPATCH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPATCH3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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