Seroatlas · Human Serome Atlas

GPATCH1

G patch domain-containing protein 1

Also known as: ECGP, FLJ10206, FLJ38686, GPATC1, GPTC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRR8
Gene: GPATCH1
Ensembl: ENSG00000076650
Chromosome: 19
Canonical length: 931 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Primary cilium,Cytosol

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

931 residues, UniProt reviewed canonical sequence.

>Q9BRR8|GPATCH1
     1  MAARDSDSEE DLVSYGTGLE PLEEGERPKK PIPLQDQTVR DEKGRYKRFH GAFSGGFSAG
    61  YFNTVGSKEG WTPSTFVSSR QNRADKSVLG PEDFMDEEDL SEFGIAPKAI VTTDDFASKT
   121  KDRIREKARQ LAAATAPIPG ATLLDDLITP AKLSVGFELL RKMGWKEGQG VGPRVKRRPR
   181  RQKPDPGVKI YGCALPPGSS EGSEGEDDDY LPDNVTFAPK DVTPVDFTPK DNVHGLAYKG
   241  LDPHQALFGT SGEHFNLFSG GSERAGDLGE IGLNKGRKLG ISGQAFGVGA LEEEDDDIYA
   301  TETLSKYDTV LKDEEPGDGL YGWTAPRQYK NQKESEKDLR YVGKILDGFS LASKPLSSKK
   361  IYPPPELPRD YRPVHYFRPM VAATSENSHL LQVLSESAGK ATPDPGTHSK HQLNASKRAE
   421  LLGETPIQGS ATSVLEFLSQ KDKERIKEMK QATDLKAAQL KARSLAQNAQ SSRAQLSPAA
   481  AAGHCSWNMA LGGGTATLKA SNFKPFAKDP EKQKRYDEFL VHMKQGQKDA LERCLDPSMT
   541  EWERGRERDE FARAALLYAS SHSTLSSRFT HAKEEDDSDQ VEVPRDQEND VGDKQSAVKM
   601  KMFGKLTRDT FEWHPDKLLC KRFNVPDPYP DSTLVGLPRV KRDKYSVFNF LTLPETASLP
   661  TTQASSEKVS QHRGPDKSRK PSRWDTSKHE KKEDSISEFL SLARSKAEPP KQQSSPLVNK
   721  EEEHAPELSA NQTVNKDVDA QAEGEGSRPS MDLFRAIFAS SSDEKSSSSE DEQGDSEDDQ
   781  AGSGEANFQS SQDTDLGETS SVAHALVPAP QEPPPSFPIQ KMQIDEREEF GPRLPPVFCP
   841  NARQTLEVPQ KEKHKKNKDK HKAKKEHRRK KEKKKKHRKH KHKGKQKNKK PEKSSSSESS
   901  DSSDSQSDEE TADVSPQELL RRLKSLPLRR Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPATCH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 6.1 nTPM
parathyroid gland: 5.9 nTPM
ovary: 5.7 nTPM
thymus: 5.5 nTPM
skin: 5.3 nTPM
duodenum: 5.1 nTPM

Single-cell type

foveolar cells: 47 nCPM
cone photoreceptor cells: 46 nCPM
retinal ganglion cells: 27 nCPM
early primary spermatocytes: 25 nCPM
adipocytes: 24 nCPM
erythrocyte progenitors: 24 nCPM

Immune cell

basophil: 23 nTPM
naive CD4 T-cell: 9.6 nTPM
T-reg: 9.2 nTPM
memory CD8 T-cell: 7.7 nTPM
eosinophil: 7.4 nTPM
naive B-cell: 7 nTPM

Brain region

cerebellum: 12 nTPM
cerebral cortex: 8 nTPM
white matter: 7.8 nTPM
basal ganglia: 7.7 nTPM
thalamus: 7.7 nTPM
midbrain: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

G-patch domain
G-patch domain
G patch domain-containing protein, N-terminal
Protein of unknown function (DUF1604)
TGH-like, helix-turn-helix domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPATCH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SNRNP40

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPATCH1 as an antibody target. Whether an autoantibody or antibody against GPATCH1 could matter depends on whether native GPATCH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPATCH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPATCH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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