Seroatlas · Human Serome Atlas

GPAT4

Glycerol-3-phosphate acyltransferase 4

Also known as: AGPAT6, DKFZp586M1819, GPAT4_HUMAN, LPAAT-zeta, TSARG7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UL3
Gene
GPAT4
Ensembl
ENSG00000158669
Chromosome
8
Canonical length
456 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q86UL3|GPAT4
     1  MFLLLPFDSL IVNLLGISLT VLFTLLLVFI IVPAIFGVSF GIRKLYMKSL LKIFAWATLR
    61  MERGAKEKNH QLYKPYTNGI IAKDPTSLEE EIKEIRRSGS SKALDNTPEF ELSDIFYFCR
   121  KGMETIMDDE VTKRFSAEEL ESWNLLSRTN YNFQYISLRL TVLWGLGVLI RYCFLLPLRI
   181  ALAFTGISLL VVGTTVVGYL PNGRFKEFMS KHVHLMCYRI CVRALTAIIT YHDRENRPRN
   241  GGICVANHTS PIDVIILASD GYYAMVGQVH GGLMGVIQRA MVKACPHVWF ERSEVKDRHL
   301  VAKRLTEHVQ DKSKLPILIF PEGTCINNTS VMMFKKGSFE IGATVYPVAI KYDPQFGDAF
   361  WNSSKYGMVT YLLRMMTSWA IVCSVWYLPP MTREADEDAV QFANRVKSAI ARQGGLVDLL
   421  WDGGLKREKV KDTFKEEQQK LYSKMIVGNH KDRSRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPAT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 50 nTPM
  • cerebellum: 46 nTPM
  • breast: 40 nTPM
  • parathyroid gland: 38 nTPM
  • tongue: 37 nTPM
  • smooth muscle: 31 nTPM

Single-cell type

  • breast lactating cells: 385 nCPM
  • neutrophils: 250 nCPM
  • monocytes: 91 nCPM
  • late spermatids: 89 nCPM
  • mast cells: 86 nCPM
  • melanocytes: 77 nCPM

Immune cell

  • myeloid DC: 21 nTPM
  • classical monocyte: 17 nTPM
  • basophil: 16 nTPM
  • intermediate monocyte: 16 nTPM
  • non-classical monocyte: 14 nTPM
  • total PBMC: 14 nTPM

Brain region

  • cerebellum: 58 nTPM
  • choroid plexus: 49 nTPM
  • cerebral cortex: 34 nTPM
  • midbrain: 32 nTPM
  • medulla oblongata: 31 nTPM
  • white matter: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.09
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPAT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPAT4 as an antibody target. Whether an autoantibody or antibody against GPAT4 could matter depends on whether native GPAT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPAT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPAT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPAT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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