Seroatlas · Human Serome Atlas

GPAT3

Glycerol-3-phosphate acyltransferase 3

Also known as: AGPAT10, AGPAT9, GPAT3_HUMAN, HMFN0839, LPAAT-theta, MAG1, MGC11324

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53EU6
Gene: GPAT3
Ensembl: ENSG00000138678
Chromosome: 4
Canonical length: 434 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q53EU6|GPAT3
     1  MEGAELAGKI LSTWLTLVLG FILLPSVFGV SLGISEIYMK ILVKTLEWAT IRIEKGTPKE
    61  SILKNSASVG IIQRDESPME KGLSGLRGRD FELSDVFYFS KKGLEAIVED EVTQRFSSEE
   121  LVSWNLLTRT NVNFQYISLR LTMVWVLGVI VRYCVLLPLR VTLAFIGISL LVIGTTLVGQ
   181  LPDSSLKNWL SELVHLTCCR ICVRALSGTI HYHNKQYRPQ KGGICVANHT SPIDVLILTT
   241  DGCYAMVGQV HGGLMGIIQR AMVKACPHVW FERSEMKDRH LVTKRLKEHI ADKKKLPILI
   301  FPEGTCINNT SVMMFKKGSF EIGGTIHPVA IKYNPQFGDA FWNSSKYNMV SYLLRMMTSW
   361  AIVCDVWYMP PMTREEGEDA VQFANRVKSA IAIQGGLTEL PWDGGLKRAK VKDIFKEEQQ
   421  KNYSKMIVGN GSLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

kidney: 83 nTPM
duodenum: 38 nTPM
skeletal muscle: 36 nTPM
small intestine: 34 nTPM
heart muscle: 24 nTPM
parathyroid gland: 22 nTPM

Single-cell type

cdc: 787 nCPM
renal collecting duct intercalated cells: 731 nCPM
distal convoluted tubule cells: 398 nCPM
mast cells: 332 nCPM
neutrophils: 315 nCPM
cardiomyocytes: 281 nCPM

Immune cell

basophil: 183 nTPM
neutrophil: 91 nTPM
myeloid DC: 81 nTPM
classical monocyte: 33 nTPM
intermediate monocyte: 28 nTPM
non-classical monocyte: 24 nTPM

Brain region

choroid plexus: 20 nTPM
pons: 12 nTPM
medulla oblongata: 9.1 nTPM
cerebellum: 8.1 nTPM
midbrain: 6.9 nTPM
cerebral cortex: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPAT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CHP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPAT3 as an antibody target. Whether an autoantibody or antibody against GPAT3 could matter depends on whether native GPAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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