Seroatlas · Human Serome Atlas

GPANK1

G patch domain and ankyrin repeat-containing protein 1

Also known as: ANKRD59, BAT4, D6S54E, G5, GPAN1_HUMAN, GPATCH10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95872
Gene
GPANK1
Ensembl
ENSG00000204438
Chromosome
6
Canonical length
356 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>O95872|GPANK1
     1  MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD ESSAPDSQRS
    61  QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL
   121  RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA
   181  AQLAEEAGFP EVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL
   241  SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS
   301  APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPANK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • testis: 35 nTPM
  • skeletal muscle: 27 nTPM
  • heart muscle: 20 nTPM
  • ovary: 17 nTPM
  • blood vessel: 16 nTPM
  • spleen: 16 nTPM

Single-cell type

  • late primary spermatocytes: 96 nCPM
  • early primary spermatocytes: 62 nCPM
  • oocytes: 41 nCPM
  • differentiating spermatogonia: 29 nCPM
  • late spermatids: 28 nCPM
  • enterocytes: 19 nCPM

Immune cell

  • basophil: 12 nTPM
  • eosinophil: 9.9 nTPM
  • neutrophil: 9.5 nTPM
  • T-reg: 4.7 nTPM
  • NK-cell: 4.5 nTPM
  • gdT-cell: 4.1 nTPM

Brain region

  • cerebellum: 10 nTPM
  • white matter: 7.7 nTPM
  • pons: 7.4 nTPM
  • medulla oblongata: 7.1 nTPM
  • cerebral cortex: 7 nTPM
  • thalamus: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPANK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPANK1 as an antibody target. Whether an autoantibody or antibody against GPANK1 could matter depends on whether native GPANK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPANK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPANK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPANK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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