GPALPP1
GPALPP motifs-containing protein 1
Also known as: AD029, bA245H20.2, GPAM1_HUMAN, KIAA1704, LSR7
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IXQ4
- Gene
- GPALPP1
- Ensembl
- ENSG00000133114
- Chromosome
- 13
- Canonical length
- 340 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli rim
OverviewNCBI Gene
No narrative summary is available for GPALPP1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
340 residues, UniProt reviewed canonical sequence.
>Q8IXQ4|GPALPP1
1 MARDLIGPAL PPGFKARGTA EDEERDPSPV AGPALPPNYK SSSSDSSDSD EDSSSLYEEG
61 NQESEEDDSG PTARKQRKNQ DDDDDDDDGF FGPALPPGFK KQDDSPPRPI IGPALPPGFI
121 KSTQKSDKGR DDPGQQETDS SEDEDIIGPM PAKGPVNYNV TTEFEKRAQR MKEKLTKGDD
181 DSSKPIVRES WMTELPPEMK DFGLGPRTFK RRADDTSGDR SIWTDTPADR ERKAKETQEA
241 RKSSSKKDEE HILSGRDKRL AEQVSSYNES KRSESLMDIH HKKLKSKAAE DKNKPQERIP
301 FDRDKDLKVN RFDEAQKKAL IKKSRELNTR FSHGKGNMFLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPALPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 6 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 6 nTPM
- retina: 5.2 nTPM
- cerebellum: 4.5 nTPM
- lymph node: 4 nTPM
- ovary: 3.8 nTPM
- endometrium: 3.4 nTPM
Single-cell type
- brain inhibitory neurons: 85 nCPM
- sertoli cells: 84 nCPM
- brain excitatory neurons: 79 nCPM
- oligodendrocyte progenitor cells: 73 nCPM
- myonuclei: 70 nCPM
- lactotrophs: 68 nCPM
Immune cell
- eosinophil: 6.7 nTPM
- naive B-cell: 6.3 nTPM
- plasmacytoid DC: 5.8 nTPM
- memory B-cell: 4.8 nTPM
- naive CD4 T-cell: 4.8 nTPM
- myeloid DC: 4.4 nTPM
Brain region
- cerebellum: 22 nTPM
- cerebral cortex: 19 nTPM
- white matter: 19 nTPM
- basal ganglia: 18 nTPM
- hypothalamus: 18 nTPM
- amygdala: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Domain of unknown function DUF3752
- GPALPP motifs-containing protein 1-like
- Protein of unknown function (DUF3752)
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPALPP1 as an antibody target. Whether an autoantibody or antibody against GPALPP1 could matter depends on whether native GPALPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPALPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GPALPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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