Seroatlas · Human Serome Atlas

GOT1L1

Putative aspartate aminotransferase, cytoplasmic 2

Also known as: AATC2_HUMAN, MGC33309

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHS2
Gene: GOT1L1
Ensembl: ENSG00000169154
Chromosome: 8
Canonical length: 421 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q8NHS2|GOT1L1
     1  MPTLSVFMDV PLAHKLEGSL LKTYKQDDYP NKIFLAYRVC MTNEGHPWVS LVVQKTRLQI
    61  SQDPSLNYEY LPTMGLKSFI QASLALLFGK HSQAIVENRV GGVHTVGDSG AFQLGVQFLR
   121  AWHKDARIVY IISSQKELHG LVFQDMGFTV YEYSVWDPKK LCMDPDILLN VVEQIPHGCV
   181  LVMGNIIDCK LTPSGWAKLM SMIKSKQIFP FFDIPCQGLY TSDLEEDTRI LQYFVSQGFE
   241  FFCSQSLSKN FGIYDEGVGM LVVVAVNNQQ LLCVLSQLEG LAQALWLNPP NTGARVITSI
   301  LCNPALLGEW KQSLKEVVEN IMLTKEKVKE KLQLLGTPGS WGHITEQSGT HGYLGLNSQQ
   361  VEYLVRKKHI YIPKNGQINF SCINANNINY ITEGINEAVL LTESSEMCLP KEKKTLIGIK
   421  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOT1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
epididymis: 0.4 nTPM
gallbladder: 0.2 nTPM
ovary: 0.2 nTPM
placenta: 0.1 nTPM
urinary bladder: 0.1 nTPM

Single-cell type

early spermatids: 92 nCPM
late primary spermatocytes: 83 nCPM
late spermatids: 14 nCPM
sertoli cells: 1.1 nCPM
lymphatic endothelial cells: 0.3 nCPM
differentiating spermatogonia: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 1.4 nTPM
hippocampal formation: 0.8 nTPM
cerebral cortex: 0.7 nTPM
basal ganglia: 0.3 nTPM
white matter: 0.3 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

aspartate biosynthetic process

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOT1L1 as an antibody target. Whether an autoantibody or antibody against GOT1L1 could matter depends on whether native GOT1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOT1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOT1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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