Seroatlas · Human Serome Atlas

GOT1

Aspartate aminotransferase, cytoplasmic

Also known as: AATC_HUMAN, AST, AST1, SGOT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17174
Gene
GOT1
Ensembl
ENSG00000120053
Chromosome
10
Canonical length
413 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>P17174|GOT1
     1  MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV LPVVKKVEQK
    61  IANDNSLNHE YLPILGLAEF RSCASRLALG DDSPALKEKR VGGVQSLGGT GALRIGADFL
   121  ARWYNGTNNK NTPVYVSSPT WENHNAVFSA AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN
   181  APEFSIVVLH ACAHNPTGID PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA
   241  IRYFVSEGFE FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP
   301  AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT WNHITDQIGM
   361  FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY VATSIHEAVT KIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
945 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 945 nTPM
  • heart muscle: 479 nTPM
  • skeletal muscle: 459 nTPM
  • liver: 347 nTPM
  • cerebral cortex: 163 nTPM
  • parathyroid gland: 134 nTPM

Single-cell type

  • late primary spermatocytes: 305 nCPM
  • retinal ganglion cells: 240 nCPM
  • enterocytes: 226 nCPM
  • parietal cells: 198 nCPM
  • hepatocytes: 196 nCPM
  • thymic myoid cells: 178 nCPM

Immune cell

  • plasmacytoid DC: 36 nTPM
  • non-classical monocyte: 32 nTPM
  • T-reg: 28 nTPM
  • intermediate monocyte: 26 nTPM
  • naive CD8 T-cell: 23 nTPM
  • myeloid DC: 22 nTPM

Brain region

  • cerebral cortex: 213 nTPM
  • choroid plexus: 140 nTPM
  • pons: 140 nTPM
  • hypothalamus: 128 nTPM
  • medulla oblongata: 115 nTPM
  • cerebellum: 112 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GOT1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 67 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • ASPARTATE AMINOTRANSFERASE, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
1.95
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOT1 as an antibody target. Whether an autoantibody or antibody against GOT1 could matter depends on whether native GOT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GOT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...