Seroatlas · Human Serome Atlas

GOLM2

Protein GOLM2

Also known as: CASC4, DKFZp459F1927, GOLM2_HUMAN, H63

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P4E1
Gene: GOLM2
Ensembl: ENSG00000166734
Chromosome: 15
Canonical length: 436 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q6P4E1|GOLM2
     1  MVGFGANRRA GRLPSLVLVV LLVVIVVLAF NYWSISSRHV LLQEEVAELQ GQVQRTEVAR
    61  GRLEKRNSDL LLLVDTHKKQ IDQKEADYGR LSSRLQAREG LGKRCEDDKV KLQNNISYQM
   121  ADIHHLKEQL AELRQEFLRQ EDQLQDYRKN NTYLVKRLEY ESFQCGQQMK ELRAQHEENI
   181  KKLADQFLEE QKQETQKIQS NDGKELDINN QVVPKNIPKV AENVADKNEE PSSNHIPHGK
   241  EQIKRGGDAG MPGIEENDLA KVDDLPPALR KPPISVSQHE SHQAISHLPT GQPLSPNMPP
   301  DSHINHNGNP GTSKQNPSSP LQRLIPGSNL DSEPRIQTDI LKQATKDRVS DFHKLKQSRF
   361  FDENESPVDP QHGSKLADYN GDDGNVGEYE ADKQAELAYN EEEDGDGGEE DVQDDEEREL
   421  QMDPADYGKQ HFNDVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 80 nTPM
thyroid gland: 79 nTPM
parathyroid gland: 77 nTPM
prostate: 63 nTPM
liver: 57 nTPM
cerebral cortex: 56 nTPM

Single-cell type

neutrophils: 388 nCPM
sertoli cells: 376 nCPM
prostatic glandular cells: 373 nCPM
retinal pigment epithelial cells: 324 nCPM
lactotrophs: 299 nCPM
adrenal cortex cells: 273 nCPM

Immune cell

neutrophil: 38 nTPM
eosinophil: 21 nTPM
basophil: 21 nTPM
non-classical monocyte: 18 nTPM
MAIT T-cell: 16 nTPM
gdT-cell: 15 nTPM

Brain region

choroid plexus: 122 nTPM
thalamus: 104 nTPM
hypothalamus: 102 nTPM
midbrain: 99 nTPM
white matter: 97 nTPM
cerebral cortex: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

GOLM1/CASC4 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLM2 as an antibody target. Whether an autoantibody or antibody against GOLM2 could matter depends on whether native GOLM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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