Seroatlas · Human Serome Atlas

GOLIM4

Golgi integral membrane protein 4

Also known as: GIMPC, GOLI4_HUMAN, GOLPH4, GPP130, P138

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00461
Gene: GOLIM4
Ensembl: ENSG00000173905
Chromosome: 3
Canonical length: 696 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>O00461|GOLIM4
     1  MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY QQHQESLSAQ
    61  LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL NKGRQDSNSR YSALNVQHQM
   121  LKSQHEELKK QHSDLEEEHR KQGEDFSRTF NDHKQKYLQL QQEKEQELSK LKETVYNLRE
   181  ENRQLRKAHQ DIHTQLQDVK QQHKNLLSEH EQLVVTLEDH KSALAAAQTQ VAEYKQLKDT
   241  LNRIPSLRKP DPAEQQNVTQ VAHSPQGYNT AREKPTREVQ EVSRNNDVWQ NHEAVPGRAE
   301  DTKLYAPTHK EAEFQAPPEP IQQEVERREP EEHQVEEEHR KALEEEEMEQ VGQAEHLEEE
   361  HDPSPEEQDR EWKEQHEQRE AANLLEGHAR AEVYPSAKPM IKFQSPYEEQ LEQQRLAVQQ
   421  VEEAQQLREH QEALHQQRLQ GHLLRQQEQQ QQQVAREMAL QRQAELEEGR PQHQEQLRQQ
   481  AHYDAMDNDI VQGAEDQGIQ GEEGAYERDN QHQDEAEGDP GNRHEPREQG PREADPESEA
   541  DRAAVEDINP ADDPNNQGED EFEEAEQVRE ENLPDENEEQ KQSNQKQENT EVEEHLVMAG
   601  NPDQQEDNVD EQYQEEAEEE VQEDLTEEKK RELEHNAEET YGENDENTDD KNNDGEEQEV
   661  RDDNRPKGRE EHYEEEEEEE EDGAAVAEKS HRRAEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLIM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

small intestine: 80 nTPM
duodenum: 62 nTPM
liver: 55 nTPM
heart muscle: 51 nTPM
colon: 50 nTPM
retina: 49 nTPM

Single-cell type

müller glia: 408 nCPM
podocytes: 323 nCPM
hepatocytes: 237 nCPM
enterocytes: 234 nCPM
bergmann glia: 223 nCPM
gastric chief cells: 206 nCPM

Immune cell

eosinophil: 11 nTPM
NK-cell: 5.5 nTPM
plasmacytoid DC: 4 nTPM
myeloid DC: 3.3 nTPM
basophil: 3.2 nTPM
intermediate monocyte: 2.8 nTPM

Brain region

medulla oblongata: 89 nTPM
spinal cord: 79 nTPM
hypothalamus: 79 nTPM
white matter: 73 nTPM
cerebral cortex: 71 nTPM
midbrain: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Golgi integral membrane protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLIM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EPHA2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLIM4 as an antibody target. Whether an autoantibody or antibody against GOLIM4 could matter depends on whether native GOLIM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLIM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLIM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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