Seroatlas · Human Serome Atlas

GOLGA8T

Golgin subfamily A member 8T

Also known as: GOG8T_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H3BQL2
Gene: GOLGA8T
Ensembl: ENSG00000261247
Chromosome: 15
Canonical length: 631 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>H3BQL2|GOLGA8T
     1  MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPEKATSGG CQPPRDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNKKQKAKRV LEVQIQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
   181  ESVLSNVMAT QKKKANQLSS RSKARTEWKL EQSMREETLL KVQLTQLKES FQQVQLERDE
   241  YSEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ELQAQVKKNQ RISLLNQRQE ERIQEQEERL RKQEERIQEQ
   361  HKSLQQLAKP QSVFEEPNNE NKNALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
   421  ALPGEGHGGE HLDSEGEEAP QPMPSVPEDL ESREAMSSFM DHLKEKADLS ELVKKELCFI
   481  HHWRDRRHQK THHLLSEPGG CAKDAALGGG HHQAGAQGGD EGEAAGAAAD GIAAYSNYNN
   541  GHRKFLAAAH NPADEPGPGA PAPQELGAAD KHGDLREVSL TSSAQGEARE DPLLDKPTAQ
   601  PIVQDHQEHP GLGSNCCVPF LCWAWLPRRR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8T can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

testis: 5.5 nTPM
thyroid gland: 2 nTPM
pancreas: 1.7 nTPM
pituitary gland: 1.4 nTPM
heart muscle: 1.1 nTPM
ovary: 1.1 nTPM

Single-cell type

late primary spermatocytes: 0.6 nCPM
podocytes: 0.3 nCPM
renal connecting tubule cells: 0.3 nCPM
vascular smooth muscle cells: 0.3 nCPM
astrocytes: 0.2 nCPM
brain inhibitory neurons: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 1.2 nTPM
basal ganglia: 1 nTPM
choroid plexus: 1 nTPM
pons: 0.7 nTPM
white matter: 0.7 nTPM
midbrain: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -2.16

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8T as an antibody target. Whether an autoantibody or antibody against GOLGA8T could matter depends on whether native GOLGA8T is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8T is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8T as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...