Seroatlas · Human Serome Atlas

GOLGA8S

Golgin subfamily A member 8S

Also known as: GOG8S_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H3BPF8
Gene: GOLGA8S
Ensembl: ENSG00000261739
Chromosome: 15
Canonical length: 638 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>H3BPF8|GOLGA8S
     1  MWPQARLPPH PAMAEETRQS KLAAAKRKLK EYWQRNSPGV PAGAKRNRKT NGSIHETATS
    61  GGCHSPGDSA TGIHGESPTS SATLKDLESP CQELAVVPDS RSVKVSQLKN TIKSLKQQKK
   121  QVVHQLEEEK KANNEKQKAE RELEVQIQRL NIQKGKLNTD LYHTKRSLRY FEEESKDLAV
   181  RLQHSLQRKG ELERALSAVT ATQKKKAERQ FSSRSKARTE WKLEQSMREQ ALLKAQLTQL
   241  KESLKEVQLE RDEYAEHLKG ERARWQQRMR KMSQEVCSLK KEKKHDKYRV ETLERSLSKL
   301  KNQMAEPLPP EPPAVPSEAE LQHLRKELER VAGALQAQVE YNQRISLLNE GQKERLREQQ
   361  ERLPEQEERL QQLAEPQNSF KELNNENKSV LQLEQQVKEL QEKLGKERLE AASQQKQQLT
   421  AQLSLMALPG EGDGGGHLDS EGEEAPRPIP SIPQDLESRE AMSSFMDHLE EKADLSELVK
   481  KQELRFIQYW QERCHQKIHH LLSEPGGRAK DAALGGGHHQ AGAQGGDEDE AAGAAADGIA
   541  AYSNYNNGHR KFLAAAHNPA DEPGPGAPAP QELGAADKHG DLCEVSLTSS AQGEAREDPL
   601  LDKPTAQPIV QDHQEHPGLG NNCCVPFFCW AWLPRRRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8S can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 3.2 nTPM

Expression across tissuesHPA

Tissue

testis: 3.2 nTPM
pancreas: 0.7 nTPM
bone marrow: 0.4 nTPM
cerebral cortex: 0.3 nTPM
duodenum: 0.3 nTPM
adipose tissue: 0.2 nTPM

Single-cell type

late primary spermatocytes: 3.9 nCPM
early spermatids: 1.7 nCPM
late spermatids: 0.7 nCPM
cardiomyocytes: 0.6 nCPM
loop of henle epithelial cells: 0.6 nCPM
podocytes: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2 nTPM
pons: 1.9 nTPM
medulla oblongata: 1.1 nTPM
midbrain: 0.5 nTPM
spinal cord: 0.5 nTPM
white matter: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.98
gnomAD pLI: 0
gnomAD missense Z: -4.44

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8S as an antibody target. Whether an autoantibody or antibody against GOLGA8S could matter depends on whether native GOLGA8S is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8S is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8S as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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