Seroatlas · Human Serome Atlas

GOLGA8R

Golgin subfamily A member 8R

Also known as: GOG8R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: I6L899
Gene: GOLGA8R
Ensembl: ENSG00000186399
Chromosome: 15
Canonical length: 631 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>I6L899|GOLGA8R
     1  MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNERQKAERV LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL
   181  ERALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE
   241  CAEHIEGERA RWHQRMSKMS QEICTLKKEK QDMRWVEQLE WSLSKLKNQT AEPLPPEPPA
   301  VPSEVELQHL RKELERVAGE LQSQVKNNQH ISLLNRRQEE RIREQEERLR KQEERLQEQH
   361  EKLRQLAKPQ SVFEELNNEN KSTLQLEQQV KELQEKLGEE HLEVASQQNQ QLTAQLSLMA
   421  LPGEGHGGEH LDSEGEEAPQ PMPSVPEDPE SREAMSSFMD HLKEKADLSE LLKKQELRFI
   481  QYWQERCHQK IHHLLSEPGG RAKDAALGGG HHQAGAQGGD EGEAAGAAAD GIAAYSNYNN
   541  GHRKFLAAAH NSADEPGPGA PAPQELGAAD KHGDLREVTL TSSAQGEARE DPLLDKPTAQ
   601  PIVQDHQEHP GLGSNCCVPL FCWAWLPRRR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 12 nTPM
pituitary gland: 7 nTPM
ovary: 6.1 nTPM
blood vessel: 5.1 nTPM
testis: 5 nTPM
bone marrow: 4.9 nTPM

Single-cell type

pdcs: 1.8 nCPM
gastric chief cells: 1.1 nCPM
late spermatids: 1.1 nCPM
adipocytes: 1 nCPM
cdc: 1 nCPM
kupffer cells: 1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 3.7 nTPM
medulla oblongata: 2.9 nTPM
choroid plexus: 2.8 nTPM
pons: 2.8 nTPM
thalamus: 2.8 nTPM
basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.98
gnomAD pLI: 0
gnomAD missense Z: -1.24
DepMap mean gene effect: -0.58
DepMap dependency class: common

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8R as an antibody target. Whether an autoantibody or antibody against GOLGA8R could matter depends on whether native GOLGA8R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8R is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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