Seroatlas · Human Serome Atlas

GOLGA8Q

Golgin subfamily A member 8Q

Also known as: GOG8Q_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H3BV12
Gene: GOLGA8Q
Ensembl: ENSG00000178115
Chromosome: 15
Canonical length: 632 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>H3BV12|GOLGA8Q
     1  MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNERQKAERE LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL
   181  ERALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE
   241  CAEHIEGERA RWHQRMSKML QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL RKQEERLQEQ
   361  HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLNLM
   421  ALPGEGHGGE HLDSEGEEAP QPMPSVPEDL ESREAMSSFM DHLKEKADLS ELVKKQELRF
   481  IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
   541  NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA
   601  QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8Q can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 16 nTPM
epididymis: 16 nTPM
bone marrow: 4.4 nTPM
testis: 3.3 nTPM
pituitary gland: 2.9 nTPM
ovary: 2.4 nTPM

Single-cell type

epididymal principal cells: 1 nCPM
endometrial ciliated cells: 0.5 nCPM
late primary spermatocytes: 0.5 nCPM
podocytes: 0.5 nCPM
early spermatids: 0.3 nCPM
distal convoluted tubule cells: 0.2 nCPM

Immune cell

NK-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 0.9 nTPM
hippocampal formation: 0.8 nTPM
basal ganglia: 0.5 nTPM
cerebral cortex: 0.5 nTPM
midbrain: 0.5 nTPM
pons: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: -1.26

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8Q as an antibody target. Whether an autoantibody or antibody against GOLGA8Q could matter depends on whether native GOLGA8Q is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8Q is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8Q as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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