Seroatlas · Human Serome Atlas

GOLGA8N

Golgin subfamily A member 8N

Also known as: GOG8N_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: F8WBI6
Gene: GOLGA8N
Ensembl: ENSG00000232653
Chromosome: 15
Canonical length: 632 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>F8WBI6|GOLGA8N
     1  MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNERQKAERE LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL
   181  ESALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE
   241  CAEHIEGERA RWHQRMSKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL RKQEERLQEQ
   361  HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
   421  ALPGEGHGGE HLDSEGEEAP QPMPSVPEDL ESREAMSSFM DHLKEKADLS ELVKKQELRF
   481  IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
   541  NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA
   601  QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8N can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

pancreas: 23 nTPM
thyroid gland: 17 nTPM
pituitary gland: 15 nTPM
testis: 13 nTPM
ovary: 13 nTPM
blood vessel: 10 nTPM

Single-cell type

renal collecting duct intercalated cells: 13 nCPM
renal connecting tubule cells: 13 nCPM
podocytes: 13 nCPM
distal convoluted tubule cells: 12 nCPM
loop of henle epithelial cells: 11 nCPM
astrocytes: 7.8 nCPM

Immune cell

basophil: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 4.1 nTPM
medulla oblongata: 3.4 nTPM
thalamus: 3.3 nTPM
midbrain: 3.2 nTPM
pons: 3.1 nTPM
choroid plexus: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.29
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.43
DepMap dependency class: selective

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8N as an antibody target. Whether an autoantibody or antibody against GOLGA8N could matter depends on whether native GOLGA8N is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8N is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8N as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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