Seroatlas · Human Serome Atlas

GOLGA8M

Golgin subfamily A member 8M

Also known as: GOG8M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H3BSY2
Gene: GOLGA8M
Ensembl: ENSG00000188626
Chromosome: 15
Canonical length: 632 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>H3BSY2|GOLGA8M
     1  MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPQTATSGG CQPPGDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNKKQKAKRV LEVQLQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
   181  ESVLSDVMAT QKKKANQLSS PSKAGTEWKL EQSMREEALL KVQLTQLKES FQQVQLERDE
   241  YSEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ELQAQVKNNQ RISLLNQRQE ERIREQEERL RKQEERIQEQ
   361  HKSLQQLAKP QSVFEEPNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
   421  ALPGEGHGGE HLDSEGEEAP QPMPSVPEDP ESREAMSSFM DHLEEKADLS ELVKKQELRF
   481  IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
   541  NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLCEVS LTSSAQGEAR EDPLLDKPTA
   601  QPIVQDHQEH PGLGSNCCVP FFCWAWLPRR RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8M can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 21 nTPM
liver: 6.5 nTPM
ovary: 6 nTPM
testis: 4.7 nTPM
adipose tissue: 4.2 nTPM
breast: 3.7 nTPM

Single-cell type

proximal tubule cells: 9.5 nCPM
bergmann glia: 8.6 nCPM
loop of henle epithelial cells: 7.1 nCPM
astrocytes: 6.6 nCPM
distal convoluted tubule cells: 6.3 nCPM
renal collecting duct intercalated cells: 6.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 3.3 nTPM
white matter: 2.4 nTPM
medulla oblongata: 1.9 nTPM
spinal cord: 1.9 nTPM
basal ganglia: 1.8 nTPM
thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: -2.27
DepMap mean gene effect: -0.32
DepMap dependency class: selective

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8M as an antibody target. Whether an autoantibody or antibody against GOLGA8M could matter depends on whether native GOLGA8M is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8M is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8M as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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