Seroatlas · Human Serome Atlas

GOLGA8K

Golgin subfamily A member 8K

Also known as: GOG8K_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: D6RF30
Gene: GOLGA8K
Ensembl: ENSG00000249931
Chromosome: 15
Canonical length: 630 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>D6RF30|GOLGA8K
     1  MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPEKATSGG CQPPRDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNKKQKAKRV LEVQIQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
   181  ESVLSNVMAT QKKKANQLSS RSKARTEWKL EQSMREEALL KVQLTQLKES FQQVQLERDE
   241  YSEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ELQAQVKKNQ RISLLNQRQE ERIQEQEERL RKQEERIQEQ
   361  HKSLQQLAKP QSVFEEPNNE NKNALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
   421  ALPGEGHGEH LDSEGEEAPQ PMPSVPEDLE SREAMSSFMD HLKEKADLSE LVKKELCFIH
   481  HWRDRRHQKT HHLLSEPGGC AKDAALGGGH HQAGAQGGDE GEAAGAAADG IAAYSNYNNG
   541  HRKFLAAAHN PADEPGPGAP APQELGAADK HGDLREVSLT SSAQGEARED PLLDKPTAQP
   601  IVQDHKEHPG LGSNCCVPLF CWAWLPRRRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

testis: 4.9 nTPM
thyroid gland: 2 nTPM
pancreas: 1.5 nTPM
blood vessel: 1.2 nTPM
adipose tissue: 1 nTPM
retina: 1 nTPM

Single-cell type

late primary spermatocytes: 10 nCPM
early spermatids: 9.8 nCPM
retinal horizontal cells: 2 nCPM
early primary spermatocytes: 1.8 nCPM
microglia: 0.9 nCPM
undifferentiated spermatogonia: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 1.7 nTPM
medulla oblongata: 1.1 nTPM
pons: 1 nTPM
cerebral cortex: 0.9 nTPM
hypothalamus: 0.9 nTPM
thalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.87

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8K as an antibody target. Whether an autoantibody or antibody against GOLGA8K could matter depends on whether native GOLGA8K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8K is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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