Seroatlas · Human Serome Atlas

GOLGA8J

Golgin subfamily A member 8J

Also known as: GOG8J_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMD2
Gene: GOLGA8J
Ensembl: ENSG00000179938
Chromosome: 15
Canonical length: 632 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>A6NMD2|GOLGA8J
     1  MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPEKATSGG CQPPRDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNKKQKAKRV LEVQIQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
   181  ESVLSNVMAT QKKKANQLSS RSKARTEWKL EQSMREEALL KVQLTQFKES FQQVQLERDE
   241  YSEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ELQAQVKNNQ RISLLNQRQE ERIREQEERL RKQEERIQEQ
   361  HKSLQQLAKP QSVFKEPNNE NKNALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
   421  ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLEEKADLS ELVKKKELCF
   481  IHHWRERCHQ KTHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
   541  NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGHLCEVS LTSSAQGEAR EDPLLDKPTA
   601  QPIVQDHQEH PGLGSNCCVP FLCWAWLPRR RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8J can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

testis: 3.8 nTPM
thyroid gland: 1.2 nTPM
pituitary gland: 0.6 nTPM
spinal cord: 0.5 nTPM
blood vessel: 0.4 nTPM
liver: 0.4 nTPM

Single-cell type

early spermatids: 5.8 nCPM
late primary spermatocytes: 5.3 nCPM
late spermatids: 0.9 nCPM
sertoli cells: 0.3 nCPM
endometrial ciliated cells: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.6 nTPM
basal ganglia: 0.5 nTPM
medulla oblongata: 0.4 nTPM
pons: 0.4 nTPM
thalamus: 0.4 nTPM
cerebral cortex: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -2.67

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8J as an antibody target. Whether an autoantibody or antibody against GOLGA8J could matter depends on whether native GOLGA8J is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8J is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8J as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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