Seroatlas · Human Serome Atlas

GOLGA8IP

Putative golgin subfamily A member 8I

Also known as: GOG8I_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NC78
Gene: GOLGA8IP
Canonical length: 632 aa

OverviewNCBI Gene

No narrative summary is available for GOLGA8IP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>A6NC78|GOLGA8IP
     1  MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPQTATSGG CQPPGDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NIKKQKAKRV LEVQIQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
   181  ESVLSDVMAT QKKKANQLSS PSKAGTEWKL EQSMREEALL KVQLTQLKES FQQLQLERHE
   241  YAEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ALQAQVKNNQ RISLLNRGQE ERIREQEERL RKQEERIQEQ
   361  HKSLQQLAKP QSVFEEPNNE NKSALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
   421  ALPGEGHGGE HLDSEGEEAP QPMPSVPEDL ESREAMSSFM DHLEEKADLS ELVKKKELCF
   481  IHHWRERCHQ KTHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
   541  NGHRKFLAAA HNPADEPGPG APAPQELGAA DKHGDLCEVS LTSSAQGEAR EDPLLDKPTA
   601  QPIVQDHQEH PGLGSNCCVP FFCWAWLPRR RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8IP as an antibody target. Whether an autoantibody or antibody against GOLGA8IP could matter depends on whether native GOLGA8IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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