Seroatlas · Human Serome Atlas

GOLGA8H

Golgin subfamily A member 8H

Also known as: GOG8H_HUMAN, GOLGA6L11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CJ92
Gene: GOLGA8H
Ensembl: ENSG00000261794
Chromosome: 15
Canonical length: 632 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>P0CJ92|GOLGA8H
     1  MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SVPEKATSGG CQPPGDSATG
    61  FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
   121  NNKKQKAKRV LEVQIQTLNI QKGKLNTDLY HMKRSLRYFE EKSKDLAVCL QHSLQRKGEL
   181  ESVLSNVMAT QKKKANQLSS RSKARTEWKL EQSMREEALL KVQLTQLKES FQQVQLERDE
   241  CAEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
   301  AVPSEVELQH LRKELERVAG ELQAQVKKNQ RISLLNQRQE ERIQEQEERL RKQEERIQEQ
   361  HKSLQQLAKP QSVFEEPNNE NKNALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
   421  ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLEEKADLS ELVKKKELCF
   481  IHHWRDRCHQ KTHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
   541  NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLCEVS LTSSAQGEAR EDPLLDKPTA
   601  QPIVQDHQEH PGLGSNCCVP LLCWAWLPRR RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

testis: 4.7 nTPM
bone marrow: 3.6 nTPM
pancreas: 3.6 nTPM
blood vessel: 2.4 nTPM
thyroid gland: 2.1 nTPM
parathyroid gland: 1.5 nTPM

Single-cell type

late primary spermatocytes: 12 nCPM
early spermatids: 9.6 nCPM
early primary spermatocytes: 3.7 nCPM
fallopian tube ciliated cells: 3.1 nCPM
endometrial ciliated cells: 3 nCPM
medullary thymic epithelial cells: 2.4 nCPM

Immune cell

eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 2.7 nTPM
medulla oblongata: 2.6 nTPM
midbrain: 2.6 nTPM
pons: 2.6 nTPM
spinal cord: 2.6 nTPM
hippocampal formation: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.98
gnomAD pLI: 0
gnomAD missense Z: -4.78

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8H as an antibody target. Whether an autoantibody or antibody against GOLGA8H could matter depends on whether native GOLGA8H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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