Seroatlas · Human Serome Atlas

GOLGA8G

Golgin subfamily A member 8G

Also known as: GOG8G_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DX53
Gene: GOLGA8G
Canonical length: 648 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA8G in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>P0DX53|GOLGA8G
     1  MWPQARLPPH PAMAEETRQS KLAAAKRKLK EYWQRNSPGV PAGAKRNRKT NGSIHETATS
    61  GGCHSPGDSA TGIHGESPTS SATLKDLESP CQELAVVPDS RSVKVSQLKN TIKSLKQQNK
   121  QVEHQLEEEK KANNEKQKAE RELEVQIQRL NIQKGKLNTD LYHTKRSLRY FEEESKDLAV
   181  RLQHSLQRKG ELERALSAVT ATQKKKAERQ FSSRSKARME WKLEQSMREQ ALLKAQLTQL
   241  KESLKEVQLE RDEYAEHLKG ERARWQQRMR KMSQEVCSLK KEKKHDKYRV EKLERSLSKL
   301  KHQMAEPLPP EPPAVPSEVE LQHLRKELER VAGELQAQVE YNQRISLLNE GQKERLREQE
   361  ERLQEQQERL PEQEERLQQL AEPQNSFKEL NNENKSVLQL EQQVKELQEK LGKERLEAAS
   421  QQKQQLTAQL SLMALPGEGD GGGHLDSEGE EAPRPIPSIP QDLESREAMS GFMDHLEEKA
   481  DLSELVEKEE LGFFQYYRER CHQKVYHPIT KPGGSAKDAA PGGGHHQAGP GQGGDEGEAA
   541  GAAGDGVAAG GDYKGHSKFL VTAQNPAHEP SPGAPAPQEL GAAHKHGDLC EVSLTDSVEP
   601  VQGEAREGSP HDNPTAQPIV QDHQEHPGLG SNCCVPFFCW AWLPRRRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 3.2 nTPM

Expression across tissuesHPA

Tissue

testis: 3.2 nTPM
basal ganglia: 0.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 0.1 nCPM
renal collecting duct principal cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.3 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0.2
gnomAD missense Z: -0.33

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cis-Golgi network

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA8G as an antibody target. Whether an autoantibody or antibody against GOLGA8G could matter depends on whether native GOLGA8G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA8G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA8G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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