GOLGA8A

Protein identityUniProt · HPA

UniProt accession

A7E2F4

Gene

GOLGA8A

Ensembl

ENSG00000175265

Chromosome

15

Canonical length

631 aa

Protein class

Predicted intracellular proteins

Subcellular location

Golgi apparatus,Cytosol

OverviewNCBI Gene

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>A7E2F4|GOLGA8A
     1  MLPVDGEERK SEGSDTEGDR TSPCAVSSAT LKDLEVGGSG RRCSDPAGQP SNLLPQRGLG
    61  APLPAETAHT QPSPNDRSLY LSPKSSSASS SLHARQSPCQ EQAAVLNSRS IKISRLNDTI
   121  KSLKQQKKQV EHQLEEEKKA NNEKQKAERE LEGQIQRLNT EKKKLNTDLY HMKHSLRYFE
   181  EESKDLAGRL QRSSQRIGEL EWSLCAVAAT QKKKPDGFSS RSKALLKRQL EQSIREQILL
   241  KGHVTQLKES LKEVQLERDQ YAEQIKGERA QWQQRMRKMS QEVCTLKEEK KHDTHRVEEL
   301  ERSLSRLKNQ MAEPLPPDAP AVSSEVELQD LRKELERVAG ELQAQVENNQ CISLLNRGQK
   361  ERLREQEERL QEQQERLRER EKRLQQLAEP QSDLEELKHE NKSALQLEQQ VKELQEKLGQ
   421  VMETLTSAEK EPEAAVPASG TGGESSGLMD LLEEKADLRE HVEKLELGFI QYRRERCHQK
   481  VHRLLTEPGD SAKDASPGGG HHQAGPGQGG EEGEAAGAAG DGVAACGSYS EGHGKFLAAA
   541  RNPAAEPSPG APAPQELGAA DKHGDLCEAS LTNSVEPAQG EAREGSSQDN PTAQPVVQLL
   601  GEMQDHQEHP GLGSNCCVPC FCWAWLPRRR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.81

gnomAD pLI

0

gnomAD missense Z

0.27

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• Golgi organization

Cellular components

• cis-Golgi network
• cytosol
• Golgi apparatus
• Golgi cis cisterna
• Golgi cisterna membrane

Protein domainsUniProt · Pfam · InterPro

• Golgin subfamily A
• Golgin subfamily A , C-terminal binding motif
• Golgin subfamily A, conserved domain
• Putative golgin subfamily A member 2-like protein 5
• GM130 C-terminal binding motif

KeywordsUniProt

• Coiled coil
• Golgi apparatus
• Membrane