Seroatlas · Human Serome Atlas

GOLGA7B

Golgin subfamily A member 7B

Also known as: bA451M19.3, bA459F3.4, C10orf132, C10orf133, GOG7B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAP0
Gene: GOLGA7B
Ensembl: ENSG00000155265
Chromosome: 10
Canonical length: 167 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables enzyme binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in Golgi membrane and plasma membrane. Predicted to be part of palmitoyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q2TAP0|GOLGA7B
     1  MATEVHNLQE LRRSASLATK VFIQRDYSDG TICQFQTKFP PELDSRIERQ LFEETVKTLN
    61  GFYAEAEKIG GSSYLEGCLA CATAYFIFLC METHYEKVLK KISRYIQEQN EKIFAPRGLL
   121  LTDPVERGMR VIEISIYEDR CSSGSSSSGS SSGSGSSSGG GGGAGAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 55 nTPM
cerebral cortex: 28 nTPM
epididymis: 22 nTPM
hippocampal formation: 22 nTPM
amygdala: 17 nTPM
hypothalamus: 16 nTPM

Single-cell type

bergmann glia: 81 nCPM
brain excitatory neurons: 38 nCPM
epididymal principal cells: 34 nCPM
astrocytes: 30 nCPM
pancreatic islet cells: 29 nCPM
other brain neurons: 27 nCPM

Immune cell

memory CD4 T-cell: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebral cortex: 35 nTPM
cerebellum: 34 nTPM
hippocampal formation: 32 nTPM
thalamus: 26 nTPM
hypothalamus: 26 nTPM
basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.01
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein targeting to membrane

Molecular functions

enzyme binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA7B as an antibody target. Whether an autoantibody or antibody against GOLGA7B could matter depends on whether native GOLGA7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA7B is annotated at the cell surface, where native GOLGA7B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GOLGA7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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