Seroatlas · Human Serome Atlas

GOLGA6L9

Golgin subfamily A member 6-like protein 9

Also known as: GG6L9_HUMAN, GOLGA6L20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NEM1
Gene
GOLGA6L9
Ensembl
ENSG00000197978
Chromosome
15
Canonical length
432 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>A6NEM1|GOLGA6L9
     1  MWPQPRLPPH PAMSEKTQQG KLAAAKKKLK AYWQRKSPGI PAGANRKKKI NGSSPDTFTS
    61  GGYHSPGDSA TGIYGEGRAS STTLQDLESQ YQELAVALDS SSAIISQLTE NINSLVRTSK
   121  EEKKHEIHLV QKLGRSLFKL KNQTAEPLAP QPPAGPSKME QLQDETNHLR KELESVGRQL
   181  QAEVENNQML SLLNRRQEER LREQEERLRE QEERLCEQEE RLCEQEERLR EQEERLCEQE
   241  KLPGQERLLE EVEKLLEQER RQEEQERLLE RERLLDEVEE LLEQERLRQQ DERLWQQETL
   301  RELERLRELE RMLELGWEAL YEQRAEPRSG FEELNNENKS TLQLEQQVKE LEKSGGAEEP
   361  RGSESAAAAR PVAGAPVPQG AWMCGQAGWT PQEHPGLSGE AVGTGEAAGG AGEAACHSFR
   421  AAENRELNIT II

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 18 nTPM
  • vagina: 13 nTPM
  • cervix: 12 nTPM
  • salivary gland: 11 nTPM
  • pancreas: 8.5 nTPM
  • stomach: 8.4 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 8.2 nCPM
  • esophageal apical cells: 6.9 nCPM
  • early spermatids: 6.5 nCPM
  • loop of henle epithelial cells: 6 nCPM
  • papillary tip epithelial cells: 6 nCPM
  • proximal tubule cells: 6 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 4.4 nTPM
  • cerebral cortex: 1 nTPM
  • white matter: 1 nTPM
  • cerebellum: 0.9 nTPM
  • basal ganglia: 0.7 nTPM
  • hippocampal formation: 0.7 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L9 as an antibody target. Whether an autoantibody or antibody against GOLGA6L9 could matter depends on whether native GOLGA6L9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GOLGA6L9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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