Seroatlas · Human Serome Atlas

GOLGA6L6

Golgin subfamily A member 6-like protein 6

Also known as: FLJ36131, GG6L6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MZA4
Gene: GOLGA6L6
Ensembl: ENSG00000277322
Chromosome: 15
Canonical length: 724 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L6 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>A8MZA4|GOLGA6L6
     1  MLMWPQPHLP THPHLPTHPH LPTHPHLPTH PHLPTHPMMS KETRQSKLAE AKEQLTDHHP
    61  QTNPSVGTAA SDTKKKKINN GTNPETTTSG GCHSPEDEQK ASHQHQEALR RELEAQVHTI
   121  RILTCQKTEL QMALYYSQHA VKQLEGEARD LISRLHDSWK FAGELEQALS AVATQKKKAD
   181  RYIEELTKER DALSLELYRN TITDEELKEK NAELQEKLQL VESEKSEIQL NVKELKRKLE
   241  RAKLLLPQQQ LQAEADHLGK ELQSVSAKLQ AQVEENELWN RLNQQQEEKM WRQEEKIQEW
   301  EEKIQEQEEK IREQEEKIRE QEEKMRRQEE MMWEKEEKMR RQEEMMWEKE EKMRRQEEMM
   361  WEKEEKIREL EEKMHEQEKI REQEEKRQEE EKIREQEKRQ EQEAKMWRQE EKIREQEEKI
   421  REQEKKMWRQ EEKIHEQEKI REEEKRQEQE EMWRQEEKIR EQEEIWRQKE KMHEQEEKIR
   481  KQEEKVWRQE EKIREQEEKI REQEEKMWRQ EEKIREQEEM WREEEKMHEQ EKIWEEEKRQ
   541  EQEDKMWRQE EKIREQEEKV WRQEEKIREQ EEKRQEQEEK MWKQEEKIRE QEEKIREQEE
   601  KIREQEEKIR EQEEMTQEQE EKMGEQEEKM CEQEEKMQEQ EETMWRQEEK IREQEKKIRE
   661  QEEKIREQEE MMQEQEEKMW EQEEKMCEQE EKMQEQEEKM RRQEEKMWEQ EVRLRQQEEK
   721  MQEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

testis: 4.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 1.9 nCPM
late primary spermatocytes: 1.1 nCPM
late spermatids: 0.5 nCPM
leydig cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
pons: 0.2 nTPM
white matter: 0.2 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -2.24
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Golgin subfamily A member 6-like

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L6 as an antibody target. Whether an autoantibody or antibody against GOLGA6L6 could matter depends on whether native GOLGA6L6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...