Seroatlas · Human Serome Atlas

GOLGA6L4

Golgin subfamily A member 6-like protein 4

Also known as: GG6L4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NEF3
Gene: GOLGA6L4
Ensembl: ENSG00000184206
Chromosome: 15
Canonical length: 574 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>A6NEF3|GOLGA6L4
     1  MWPQPRFPPH PAMSEKTQQG KLAAAKKKLK AYWQRKSPGI PAGANRKKKI NGSSPDTATS
    61  GGYHSPGDSA TGIYGEGRAS STTLEDLESQ YQELAVALDS SSAIISQLTE NINSLVRTSK
   121  EEKKHEIHLV QKLGRSLFKL KNQTAEPLAP EPPAGPSKVE QLQDETNHLR KELESVGRQL
   181  QAEVENNQML SLLNRRQEER LREQEERLRE QEERLREQED RLHEQEERLR EQEERLCEQE
   241  ERLREHEERL CEQEERLCEQ EERLREQEER LHEQEERLRE QEERLCEQEE RLREQEERLC
   301  EQEERLREQE ERLCEQEKLP GQERLLEEVE KLLEQERRQE EQERLLERER LLEEVEKLLE
   361  QERQQEEQER LLERERLLEE VEKLLEQERR QEEQERLLER ERLLDEVEEL LDEVEELLEQ
   421  ERLRQQDERL WQQETLQELE RLRELERLRE LERMLELGWE ALYEQRAEPR SGFEELNNEN
   481  KSTLQLEQQV KELKKSGGAE EPRGSESAAA ARPVAGAPVP QGAWMCGQAG WTPQEHPGLS
   541  GEAVGTGEAA GGAGEAACHS FRAAENRELN ITII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

ovary: 13 nTPM
testis: 8.2 nTPM
cervix: 5.9 nTPM
endometrium: 5.9 nTPM
adrenal gland: 5.8 nTPM
adipose tissue: 5.7 nTPM

Single-cell type

renal collecting duct intercalated cells: 10 nCPM
early spermatids: 7.5 nCPM
proximal tubule cells: 7.5 nCPM
distal convoluted tubule cells: 6.6 nCPM
renal connecting tubule cells: 4.6 nCPM
loop of henle epithelial cells: 3.9 nCPM

Immune cell

NK-cell: 2.3 nTPM
basophil: 1.1 nTPM
MAIT T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

cerebral cortex: 4.2 nTPM
choroid plexus: 4 nTPM
hypothalamus: 3.7 nTPM
basal ganglia: 3.3 nTPM
medulla oblongata: 3.1 nTPM
white matter: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0.01
gnomAD missense Z: -0.78

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L4 as an antibody target. Whether an autoantibody or antibody against GOLGA6L4 could matter depends on whether native GOLGA6L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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