Seroatlas · Human Serome Atlas

GOLGA6L26

Golgin subfamily A member 6-like protein 26

Also known as: GG6LZ_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DX02
Gene: GOLGA6L26
Canonical length: 649 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L26 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

649 residues, UniProt reviewed canonical sequence.

>P0DX02|GOLGA6L26
     1  MWPQPHLPTH PHLPTHPHLP THPMMSKETR QSKLAEAKEQ LTDHHPQTNP SVGTAASDTK
    61  KKKINNGTNP ETTTSGGCHS PEDEQKASHQ HQEALRRELE AQVHTIRILT CQKTELQMAL
   121  YYSQHAVKQL EGEARDLISR LHDSWKFAGE LEQALSAVAT QKKKADRYIE ELTKERDALS
   181  LELYRNTITD EELKEKNAKL QEKLQLVESE KSEIQLNVKE LKRKLERAKL LLPQQQLQAE
   241  ADHLGKELQS VSAKLQAQVE ENELWNRLNQ QQEEKMWRQE EKIQEWEEKI QEQEEKIREQ
   301  EEKIREQEEK MRRQEEMMWE KEEKMRRQEE MMWEKEEKMR RLEEMMWEKE EKIRELEEKM
   361  HEQEKIREQE EKRQEEEKIR EQEKRQEQEA KMWRQEEKIR EQEEKIREQE KKMWRQEEKI
   421  HEQEKIREEE KRQEQEEMWR QEEKIREQEE IWRQKEKMHE QEKIRKQEEK VWRQEEKMHD
   481  QEEKIREQEE KMWRQEEKIR EQEEKIREQE EKIREQEEKI REQEEMMQEQ EEKMGEQEEK
   541  MQEQEKMRRQ EEKIREQEEK IREQKEKIRE QEEKIWEQEE KIREQEEMMQ EQEEKMWEQE
   601  EKMCEQEEKM QEQEEKMRRQ EEKMWEQEVR LRQQEEKMQE HQEHLEAAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM
breast: 0 nTPM

Single-cell type

early spermatids: 0.6 nCPM
late primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.2 nTPM
spinal cord: 0.2 nTPM
thalamus: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Protein domainsUniProt · Pfam · InterPro

Golgin subfamily A member 6-like

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L26 as an antibody target. Whether an autoantibody or antibody against GOLGA6L26 could matter depends on whether native GOLGA6L26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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