Seroatlas · Human Serome Atlas

GOLGA6L25

Golgin subfamily A member 6-like protein 25

Also known as: GG6LY_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DX01
Gene: GOLGA6L25
Canonical length: 826 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L25 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

826 residues, UniProt reviewed canonical sequence.

>P0DX01|GOLGA6L25
     1  MWPQPHLPTH PHLPTHPHLP THPHLPTHPM MSKETRQSKL AEAKEQLTDH HPQTNPSVGT
    61  AASDTKKKKI NNGTNPETTT SGGCHSPEDE QKASHQHQEA LRRELEAQVH TIRILTCQKT
   121  ELQMALYYSQ HAVKQLEGEA RDLISRLHDS WKFAGELEQA LSAVATQKKK ADRYIEELTK
   181  ERDALSLELY RNTITDEELK EKNAKLQEKL QLVESEKSEI QLNVKELKRK LERAKLLLPQ
   241  QQLQAEADHL GKELQSVSAK LQAQVEENEL WNRLNQQQEE KMWRQEEKIQ EREEKIQEQE
   301  EKIREQEEKM RRQEEMMWEK EEKMRRQEEM MWEKEEKIRE LEEKMHEQEK IREQEEKRQE
   361  EEKIREQEKR QEQEAKMWRQ EEKIREQEEK IREQEKKMWR QEEKIHEQEK IREEEKRQEQ
   421  EEMWRQEEKI REQEEIWRQK EKMHEQEEKI RKQEEKVWRQ EEKMHDQEEK IREQEEKVWR
   481  QEEKIREQEE KMWRQEEKIR EQEEMWREEE KMHEQEKIWE EEKRQEQEDK MWRQEEKIRE
   541  QEEKVWRQEE KIREQEEKRQ EQEEKMWKQE EKIREQEEKI REQEKIREQE EKIREQEEMM
   601  QEQEEKMGEQ EEKMQEQEKM RRQEEKIREQ EEKIREQKEK IREQEEKIWE QEEKIREQEE
   661  MMQEQEEKMG EQEEKMWEQE EEMQEQEEKM RRQEEKIREQ EKKIREQEEK IREQEEMMQE
   721  QEEKMGEQEG KMCEQEAKMQ EQEEKMRRQE EKIREQEKKI REQEEKIREQ EEMMQEQEEK
   781  MWEQEEKMCE QEEKMQEQEE KMRRQEEKMR EQEVRLRQQE EKMQEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM
breast: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

Golgin subfamily A member 6-like

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L25 as an antibody target. Whether an autoantibody or antibody against GOLGA6L25 could matter depends on whether native GOLGA6L25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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