Seroatlas · Human Serome Atlas

GOLGA6L22

Golgin subfamily A member 6-like protein 22

Also known as: GG6LV_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H0YM25
Gene: GOLGA6L22
Ensembl: ENSG00000277865
Chromosome: 15
Canonical length: 854 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L22 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

854 residues, UniProt reviewed canonical sequence.

>H0YM25|GOLGA6L22
     1  MLMWPQPHLP THPHLPTHPH LPTHPHLPTH PHLPTHPHLP THPMMSKETR QSKLAEAKEQ
    61  LTDHHPQTNP SVGTAASDTK KKKINNGTSP ETTTSGGCHS PEDEQKASHQ HQEALRRELE
   121  AQVHTIRILT CQKTELQMAL YYSQHAVKQL EGEARDLISR LHDSWKFAGE LEQALSAVTT
   181  QKKKADRYIE ELTKERDALS LELYRNTITD EELKEKNAKL QEKLQLVESE KSEIQLNVKE
   241  LKRKLERAKL LLPQQQLQAE ADHLGKELQS VSAKLQAQVE ENELWNRLNQ QQEEKMWRQE
   301  EKIQEWEEKI QEQEEKIREQ EEKIREQEEK MRRQEEMMWE KEEKMRRQEE MMWEKEEKIR
   361  ELEEKMHEQE KIREQEEKRQ EEEKIREQEK RQEQEAKMWR QEEKIREQEE KIREQEKKMW
   421  RQEEKIHEQE KIREEEKRQE QEEMWRQEEK IREQEEIWRQ KEKMHEQEEK IRKQEEKVWR
   481  QEEKMHDQEE KIREQEEKVW RQEEKIREQE KKREQEEKMW RQEEKIREQE EKIREQEEMW
   541  REEEKMHEQE KIWEEEKRQE QEDKMWRQEE KIREQEEKVW RQEEKIREQE EKRQEQEEKM
   601  WKQEEKIREQ EEKIREQEEK IREQEEKIRE QEEMMQEQEE KMGEQEEKMQ EQEKMRRQEE
   661  KIREQEEKIR EQKEKIREQE EKIWEQEEKI REQEEMMQEQ EEKMGEQEEK IWEQEEKMQE
   721  QEEKMRRQEE KIREQEKKIR EQEEKIREQE EMMQEQEEKM GEQEEKMQEQ EEKMRRQEEK
   781  IREQEKKIRE QEEKIREQEE MMQEQEEKMW EQEEKMCEQE EKMQEQEEKM RRQEEKMWEQ
   841  EVRLRQQEEK MQEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

testis: 9.4 nTPM
cerebral cortex: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 18 nCPM
late primary spermatocytes: 10 nCPM
late spermatids: 2.3 nCPM
distal convoluted tubule cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

Golgin subfamily A member 6-like

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L22 as an antibody target. Whether an autoantibody or antibody against GOLGA6L22 could matter depends on whether native GOLGA6L22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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