Seroatlas · Human Serome Atlas

GOLGA6L2

Golgin subfamily A member 6-like protein 2

Also known as: CT105, FLJ36144, GG6L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9W4
Gene: GOLGA6L2
Ensembl: ENSG00000174450
Chromosome: 15
Canonical length: 909 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

909 residues, UniProt reviewed canonical sequence.

>Q8N9W4|GOLGA6L2
     1  MWPQPHLPPH PMMSEKTRQN KLAEAKKKFT DYRQWNIAGV GTRATDTKKK KINNGTNPET
    61  TTSEGCHSPE DTQQNRAQLK EEKKASHQHQ EALRREIEAQ DHTIRILTCQ KTELETALYY
   121  SQDAARKFED GNLGTPSSFN LALSQAFRGS PLGCVSTSLI PGESKDLAGR LHHSWHFAGE
   181  LQRALSAVST WHKKADRYIE ELTKERDALS LELYRNTITN EELKKKNAEL QEKLRLAESE
   241  KSEIQLNVKE LKRKLERAKF LLPQVQTNTL QEEMWRQEEE LREQEKKIRK QEEKMWRQEE
   301  RLREQEGKMR EQEEKMRRQE KRLREQEKEL REQEKELREQ KKLREQEEQM QEQEEKMWEQ
   361  EEKMREQEEK MWRQEERLWE QEKQMREQEQ KMRDQEERMW EQDERLREKE ERMREQEKMW
   421  EQVEKMREEK KMQEQEKKTR DQEEKMQEEE RIREREKKMR EEEETMREQE EKMQKQEENM
   481  WEQEEKEWQQ QRLPEQKEKL WEQEKMQEQE EKIWEQEEKI RDQEEMWGQE KKMWRQEKMR
   541  EQEDVETGGE AAGAGEADVG AGGEDAGSGA EDVGPGGEDV GAGREAAGEG GENAGAEEDV
   601  AAGGEDAGGE EDAGAGEEDM GPGGEDARGG EDAGAGEEDA GGGGDDAGAG GEDAGAGRED
   661  AGAGGEDVGA GREDAGAGGE DVGAGGEDVG AGRRRCGSSR GCRNRRRSCG NTRRCRSRRS
   721  GAEDVGPEGE DVGAGREAAG EGGENAGAED VAAGGEDAGE EEDAGGEDAG AAREDAGAGG
   781  DDVGAGREDA GAGGEDVGAG GEDAGAGGED AGAGGEDAGP GGEDAGAGGE DAGPGGEDAG
   841  AGGEDAGPGG EDVGPGGEDV GAGGEDVGAG GDAREGGEDT RSEREDAGEA ARARGAVLRA
   901  LPPSLQSSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

testis: 47 nTPM
skeletal muscle: 1.1 nTPM
heart muscle: 0.2 nTPM
cerebral cortex: 0.1 nTPM
gallbladder: 0.1 nTPM
lymph node: 0.1 nTPM

Single-cell type

late primary spermatocytes: 107 nCPM
early spermatids: 92 nCPM
late spermatids: 11 nCPM
undifferentiated spermatogonia: 0.8 nCPM
hematopoietic stem cells: 0.5 nCPM
adrenal cortex cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.8 nTPM
choroid plexus: 0.8 nTPM
cerebral cortex: 0.7 nTPM
white matter: 0.7 nTPM
hippocampal formation: 0.6 nTPM
medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.6

Protein domainsUniProt · Pfam · InterPro

Golgin subfamily A member 6-like

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L2 as an antibody target. Whether an autoantibody or antibody against GOLGA6L2 could matter depends on whether native GOLGA6L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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