Seroatlas · Human Serome Atlas

GOLGA6L19

Putative golgin subfamily A member 6-like protein 19

Also known as: GG6LS_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H0YKK7
Gene: GOLGA6L19
Canonical length: 550 aa

OverviewNCBI Gene

No narrative summary is available for GOLGA6L19 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>H0YKK7|GOLGA6L19
     1  MWPQPRLPPH PAMSEKTQQG KLAAAKKKLK AYWQRKSPGI PAGANRKKKV NGSSPDTATS
    61  GGYHSPGDSA TGVYGEGRAS STTLQDLESQ YQELAVALDS SSAIISQLTE NINSLVRTSK
   121  EEKKHEIHLV QKLGRSLFKL KNQTAEPLAP EPPAGPSKVE QLQDETNHLR KELESVGRQL
   181  QAEVENNQML SLLNRRQEER LREQEERLHE QEERLHEQEE RLCEQEERLR EQEERLCEQE
   241  ERLREQEERL CEQEERLREQ EERLCEQEER LREQEERLCE QEERLREQEE RLCEQEERLR
   301  EQEERLCEQE ERLREQEERL CEQEERLCEQ EERLCEQEER LCEQEERLCE QEKLPGQERL
   361  LEEVEKLLEQ ERRQEEQERL LERERLLDEV EELLEQERLR QQDERLWQQE TLRELERLRE
   421  LERLRELERM LELGWEALYE QRAEPRSGFE ELNNENKSTL QLEQQVKELE KSGGAEEPRG
   481  SESAAAARPV PGAPVPQGAW MCGQAGWTPQ EHPGLSGEAV GTGEAAGGAE EAACHSFRAA
   541  ENRELNITII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.77

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L19 as an antibody target. Whether an autoantibody or antibody against GOLGA6L19 could matter depends on whether native GOLGA6L19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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