Seroatlas · Human Serome Atlas

GOLGA6L10

Golgin subfamily A member 6-like protein 10

Also known as: GG6LA_HUMAN, GOLGA6L18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NI86
Gene: GOLGA6L10
Ensembl: ENSG00000278662
Chromosome: 15
Canonical length: 522 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L10 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>A6NI86|GOLGA6L10
     1  MWPQPRLPPH PAMSEKTQQG KLAAAKKKLK AYWQRKSPGI PAGANRKKKV NGSSPDTATS
    61  GGYHSPGDSA TGIYGEGRAS STTLQDLESQ YQELAVALDS SSAIISQLTE NINSLVRTSK
   121  EEKKHEIHLV QKLGRSLFKL KNQTAEPLAP EPPAGPSKVE QLQDETNHLR KELESVGRQL
   181  QAEVENNQML SLLNRRQEER LREQEERLHE QEERLHEQEE RLCEQEERLR EQEERLCEQE
   241  ERLREQEERL CEQEERLREQ EERLCEQEER LREQEERLRE QEERLCEQEE RLCEQEERLR
   301  EQEERLCEQE ERLCEQEERL CEQEKLPGQE RLLEEVEKLL EQERRQEEQE RLLERERLLD
   361  EVEELLEQER LRQQDERLWQ QETLRELERL RELERLRELE RMLELGWEAL YEQRAEPRSG
   421  FEELNNENKS TLQLEQQVKE LEKSGGAEEP RGSESAAAAR PVPGAPVPQG AWMCGQAGWT
   481  PQEHPGLSGE AVGTGEAAGG AEEAACHSFR AAENRELNIT II

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

testis: 9.2 nTPM
esophagus: 4.5 nTPM
vagina: 4 nTPM
cervix: 3.5 nTPM
salivary gland: 3.5 nTPM
ovary: 2.9 nTPM

Single-cell type

early spermatids: 85 nCPM
late primary spermatocytes: 59 nCPM
differentiating spermatogonia: 12 nCPM
late spermatids: 12 nCPM
epididymal efferent duct ciliated cells: 12 nCPM
somatotrophs: 9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.8 nTPM
cerebral cortex: 0.7 nTPM
hippocampal formation: 0.7 nTPM
amygdala: 0.6 nTPM
basal ganglia: 0.6 nTPM
hypothalamus: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GOLGA6L10.

Disease | ImmuneIEDB

Conditions an epitope on GOLGA6L10 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -1.77

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L10 as an antibody target. Whether an autoantibody or antibody against GOLGA6L10 could matter depends on whether native GOLGA6L10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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