Seroatlas · Human Serome Atlas

GOLGA6L1

Golgin subfamily A member 6-like protein 1

Also known as: GG6L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7Z2
Gene: GOLGA6L1
Ensembl: ENSG00000273976
Chromosome: 15
Canonical length: 668 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GOLGA6L1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

668 residues, UniProt reviewed canonical sequence.

>Q8N7Z2|GOLGA6L1
     1  MLMWPQPHLP THPHLPTHPH LPTHPHLPTH PHLPTHPHLP THPHLPTHPM MSKETRQSKL
    61  AEAKEQLTDH HPQTNPSVGT AASDTKKKKI NNGTNPETTT SGGCHSPEDE QKASHQHQEA
   121  LRRELEAQVH TIRILTCQKT ELQMALYYSQ HAVKQLEGEA RDLISRLHDS WKFAGELEQA
   181  LSAVATQKKK ADRYIEELTK ERDALSLELY RNTITDEELK EKNAKLQEKL QLVESEKSEI
   241  QLNVKELKRK LERAKLLLPQ QQLQAEADHL GKELQSVSAK LQAQVEENEL WNRLNQQQEE
   301  KMWRQEEKIQ EWEEKIQEQE EKIREQEEKI REQEEKMRRQ EEMMWEKEEK MRRQEEMMWE
   361  KEEKMRRLEE MMWEKEEKIR ELEEKMHEQE KIREQEEKRQ EEEKIREQEK RQEQEAKMWR
   421  QEEKIREQEE KIREQEKKMW RQEEKIHEQE KIREEEKRQE QEEMWRQEEK IREQEEIWRQ
   481  KEKMHEQEKI RKQEEKVWRQ EEKMHDQEEK IREQEEKMWR QEEKIREQEE KIREQEEKIR
   541  EQEEMMQEQE EKMGEQEEKM QEQEKMRRQE EKIREQEEKI REQKEKIREQ EEKIWEQEEK
   601  IREQEEMMQE QEEKMWEQEE KMCEQEEKMQ EQEEKMRRQE EKMWEQEVRL RQQEEKMQEH
   661  QEHLEAAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
cerebral cortex: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

papillary tip epithelial cells: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -1.76

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Golgin subfamily A member 6-like

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6L1 as an antibody target. Whether an autoantibody or antibody against GOLGA6L1 could matter depends on whether native GOLGA6L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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