Seroatlas · Human Serome Atlas

GOLGA6D

Golgin subfamily A member 6D

Also known as: GOG6D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG33
Gene
GOLGA6D
Ensembl
ENSG00000140478
Chromosome
15
Canonical length
693 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Centrosome

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>P0CG33|GOLGA6D
     1  MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS
    61  GGGHSPGDSQ YQELAVALES SSVTINQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ
   121  MEQLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQHIQ ELERALCAVS
   181  TQQQEEDRSS SCREAVLQRR LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER
   241  ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
   301  QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE AQRVREQERL
   361  CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE
   421  ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA
   481  ASQRNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE
   541  KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
   601  VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DVFYEVSLDN
   661  NVEPAPGVAR EGSPHNNPTV QQIVQLSPVM QDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
6.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.2 nTPM
  • skeletal muscle: 0.2 nTPM
  • liver: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • early spermatids: 11 nCPM
  • late primary spermatocytes: 9.6 nCPM
  • late spermatids: 2.7 nCPM
  • sertoli cells: 0.3 nCPM
  • proximal tubule cells: 0.2 nCPM
  • distal convoluted tubule cells: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.5 nTPM
  • medulla oblongata: 0.2 nTPM
  • white matter: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0
gnomAD missense Z
-0.8
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6D as an antibody target. Whether an autoantibody or antibody against GOLGA6D could matter depends on whether native GOLGA6D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GOLGA6D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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