Seroatlas · Human Serome Atlas

GOLGA6C

Golgin subfamily A member 6C

Also known as: GOG6C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDK9
Gene: GOLGA6C
Ensembl: ENSG00000167195
Chromosome: 15
Canonical length: 693 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Centrosome

OverviewNCBI Gene

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>A6NDK9|GOLGA6C
     1  MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS
    61  GGGHSPGDSQ YQELAVALES SSVTINQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ
   121  MEQLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQRIQ ELERALSAVS
   181  TQQQEEDRSS SCREAVLQRR LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER
   241  ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
   301  QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE AQRVREQERL
   361  CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE
   421  ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA
   481  ASQRNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE
   541  KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
   601  VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DDFYEVSLDN
   661  NVEPAPGAAR EGSPHDNPPV QQIVQLSPVM QDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
liver: 3.5 nTPM
skeletal muscle: 1.1 nTPM
retina: 0.5 nTPM
basal ganglia: 0.2 nTPM
blood vessel: 0.2 nTPM

Single-cell type

early spermatids: 35 nCPM
late primary spermatocytes: 24 nCPM
late spermatids: 3.3 nCPM
retinal amacrine cells: 1.1 nCPM
sertoli cells: 0.6 nCPM
endometrial luminal cells: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.3 nTPM
medulla oblongata: 1.3 nTPM
midbrain: 1.2 nTPM
white matter: 1.2 nTPM
pons: 1 nTPM
cerebral cortex: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: -1.11

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Golgi organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA6C as an antibody target. Whether an autoantibody or antibody against GOLGA6C could matter depends on whether native GOLGA6C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA6C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA6C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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