GOLGA6B

Protein identityUniProt · HPA

UniProt accession

A6NDN3

Gene

GOLGA6B

Ensembl

ENSG00000215186

Chromosome

15

Canonical length

693 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Centrosome

OverviewNCBI Gene

This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, which are greater than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosomal rearrangements that underlie genomic disease. This gene is a member of the golgin gene family, whose protein products localize to the Golgi apparatus. The majority of the related gene copies are thought to be transcribed pseudogenes. It is not known whether this gene is a pseudogene or if it encodes a golgin protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>A6NDN3|GOLGA6B
     1  MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS
    61  GGGHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ
   121  MERLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQRIQ ELERALCAVS
   181  TQQQEEDRSS SCREAVLHRR LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER
   241  ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAKPPSLAP PAVTSVVEQL
   301  QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE VQRVREQERL
   361  CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE
   421  ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA
   481  ASQQNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE
   541  KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
   601  VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DDFYEVSLDN
   661  NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

6.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.7

gnomAD pLI

0

gnomAD missense Z

-0.6

DepMap mean gene effect

-0.42

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• Golgi organization

Cellular components

• cis-Golgi network
• Golgi cis cisterna
• Golgi cisterna membrane

Protein domainsUniProt · Pfam · InterPro

• Golgin subfamily A
• Golgin subfamily A, conserved domain
• Putative golgin subfamily A member 2-like protein 5

KeywordsUniProt

• Coiled coil