Seroatlas · Human Serome Atlas

GNRHR2

Putative gonadotropin-releasing hormone II receptor

Also known as: GNRR2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P88
Gene: GNRHR2
Canonical length: 292 aa

OverviewNCBI Gene

No narrative summary is available for GNRHR2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q96P88|GNRHR2
     1  MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD RQAAVLNPLG
    61  SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ CVTKGSFKAQ WQETTYNLFT
   121  FCCLFLLPLT AMAICYSRIV LSVSRPQTRK GSHAPAGEFA LPRSFDNCPR VRLRALRLAL
   181  LILLTFILCW TPYYLLGMWY WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC
   241  RRGHQELSID SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNRHR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.42

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

gonadotropin-releasing hormone receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNRHR2 as an antibody target. Whether an autoantibody or antibody against GNRHR2 could matter depends on whether native GNRHR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNRHR2 is annotated at the cell surface, where native GNRHR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNRHR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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