Seroatlas · Human Serome Atlas

GNRH1

Progonadoliberin-1

Also known as: GNRH, GON1_HUMAN, GRH, LHRH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01148
Gene
GNRH1
Ensembl
ENSG00000147437
Chromosome
8
Canonical length
92 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>P01148|GNRH1
     1  MKPIQKLLAG LILLTWCVEG CSSQHWSYGL RPGGKRDAEN LIDSFQEIVK EVGQLAETQR
    61  FECTTHQPRS PLRDLKGALE SLIEEETGQK KI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNRH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 21 nTPM
  • cerebellum: 13 nTPM
  • blood vessel: 12 nTPM
  • ovary: 8.5 nTPM
  • retina: 8.5 nTPM
  • vagina: 8.2 nTPM

Single-cell type

  • peritubular myoid cells: 15 nCPM
  • leydig cells: 14 nCPM
  • fibro-adipogenic progenitors: 12 nCPM
  • other brain neurons: 11 nCPM
  • thymocytes: 11 nCPM
  • innate lymphoid cells: 10 nCPM

Immune cell

  • gdT-cell: 0.3 nTPM
  • T-reg: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • hypothalamus: 27 nTPM
  • basal ganglia: 12 nTPM
  • white matter: 10 nTPM
  • cerebellum: 9.9 nTPM
  • cerebral cortex: 9.9 nTPM
  • pons: 7.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNRH1.

Disease | AllUniProt

Conditions GNRH1 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 12 with or without anosmia (HH12) MIM:614841

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypogonadotropic hypogonadism 12 with or without anosmia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0.15
gnomAD missense Z
0.16
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNRH1 as an antibody target. Whether an autoantibody or antibody against GNRH1 could matter depends on whether native GNRH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNRH1 is annotated as secreted, so native GNRH1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GNRH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNRH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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