Seroatlas · Human Serome Atlas

GNPDA1

Glucosamine-6-phosphate deaminase 1

Also known as: GNPDA, GNPI, GNPI1_HUMAN, GPI, HLN, KIAA0060

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46926
Gene: GNPDA1
Ensembl: ENSG00000113552
Chromosome: 5
Canonical length: 289 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles
Quaternary structure: Homohexamer

OverviewNCBI Gene

Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>P46926|GNPDA1
     1  MKLIILEHYS QASEWAAKYI RNRIIQFNPG PEKYFTLGLP TGSTPLGCYK KLIEYYKNGD
    61  LSFKYVKTFN MDEYVGLPRD HPESYHSFMW NNFFKHIDIH PENTHILDGN AVDLQAECDA
   121  FEEKIKAAGG IELFVGGIGP DGHIAFNEPG SSLVSRTRVK TLAMDTILAN ARFFDGELTK
   181  VPTMALTVGV GTVMDAREVM ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD
   241  EDATLELKVK TVKYFKGLML VHNKLVDPLY SIKEKETEKS QSSKKPYSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNPDA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

kidney: 71 nTPM
epididymis: 49 nTPM
adrenal gland: 36 nTPM
ovary: 33 nTPM
urinary bladder: 31 nTPM
spleen: 29 nTPM

Single-cell type

hofbauer cells: 203 nCPM
kupffer cells: 104 nCPM
epicardial cells: 89 nCPM
macrophages: 70 nCPM
urothelial cells: 70 nCPM
extravillous trophoblasts: 64 nCPM

Immune cell

MAIT T-cell: 78 nTPM
intermediate monocyte: 59 nTPM
non-classical monocyte: 57 nTPM
myeloid DC: 52 nTPM
classical monocyte: 49 nTPM
total PBMC: 40 nTPM

Brain region

hypothalamus: 34 nTPM
white matter: 32 nTPM
pons: 31 nTPM
basal ganglia: 29 nTPM
thalamus: 28 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 1.79
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNPDA1 as an antibody target. Whether an autoantibody or antibody against GNPDA1 could matter depends on whether native GNPDA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNPDA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GNPDA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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