Seroatlas · Human Serome Atlas

GNGT2

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Also known as: GBGT2_HUMAN, GNG9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14610
Gene
GNGT2
Ensembl
ENSG00000167083
Chromosome
17
Canonical length
69 aa
Protein class
Predicted intracellular proteins, RAS pathway related proteins, Transporters

OverviewNCBI Gene

Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

69 residues, UniProt reviewed canonical sequence.

>O14610|GNGT2
     1  MAQDLSEKDL LKMEVEQLKK EVKNTRIPIS KAGKEIKEYV EAQAGNDPFL KGIPEDKNPF
    61  KEKGGCLIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNGT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
146 nTPM

Expression across tissuesHPA

Tissue

  • retina: 146 nTPM
  • tonsil: 17 nTPM
  • spleen: 15 nTPM
  • lymph node: 13 nTPM
  • appendix: 7.3 nTPM
  • lung: 6.8 nTPM

Single-cell type

  • cone photoreceptor cells: 385 nCPM
  • kupffer cells: 37 nCPM
  • nk-cells: 16 nCPM
  • late spermatids: 15 nCPM
  • macrophages: 12 nCPM
  • monocytes: 10 nCPM

Immune cell

  • non-classical monocyte: 67 nTPM
  • intermediate monocyte: 47 nTPM
  • gdT-cell: 31 nTPM
  • MAIT T-cell: 27 nTPM
  • NK-cell: 27 nTPM
  • memory CD8 T-cell: 21 nTPM

Brain region

  • white matter: 6.2 nTPM
  • medulla oblongata: 4.6 nTPM
  • hypothalamus: 4.3 nTPM
  • pons: 4.3 nTPM
  • spinal cord: 3.8 nTPM
  • cerebellum: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0.19
gnomAD missense Z
0.51
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNGT2 as an antibody target. Whether an autoantibody or antibody against GNGT2 could matter depends on whether native GNGT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNGT2 is annotated at the cell surface, where native GNGT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNGT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNGT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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