Seroatlas · Human Serome Atlas

GNG8

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Also known as: GBG8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK08
Gene: GNG8
Ensembl: ENSG00000167414
Chromosome: 19
Canonical length: 70 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

70 residues, UniProt reviewed canonical sequence.

>Q9UK08|GNG8
     1  MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF
    61  RDKRLFCVLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNG8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 9.4 nTPM
heart muscle: 5 nTPM
choroid plexus: 3.9 nTPM
thymus: 3.9 nTPM
appendix: 3.1 nTPM
cerebral cortex: 2.6 nTPM

Single-cell type

platelets: 192 nCPM
megakaryocytes: 93 nCPM
gonadotrophs: 11 nCPM
adrenal medulla cells: 11 nCPM
mesothelial cells: 9.2 nCPM
late spermatids: 7.3 nCPM

Immune cell

naive B-cell: 5.4 nTPM
T-reg: 3.2 nTPM
total PBMC: 2.4 nTPM
memory B-cell: 1.2 nTPM
naive CD4 T-cell: 1 nTPM
neutrophil: 0.9 nTPM

Brain region

midbrain: 43 nTPM
white matter: 32 nTPM
hypothalamus: 30 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 20 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0.16
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway
nervous system development
nose development
social behavior
cellular response to pheromone

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNG8 as an antibody target. Whether an autoantibody or antibody against GNG8 could matter depends on whether native GNG8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNG8 is annotated at the cell surface, where native GNG8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNG8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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