GNG5B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B
Also known as: GBG5B_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- A0A804HLA8
- Gene
- GNG5B
- Canonical length
- 68 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for GNG5B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
68 residues, UniProt reviewed canonical sequence.
>A0A804HLA8|GNG5B
1 MSGFSSVAAT KKVVQQLQLE AGLNSVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR
61 PQKVCSFLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GNG5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 1.5 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 1.5 nTPM
- liver: 1.3 nTPM
- epididymis: 0.5 nTPM
- cerebral cortex: 0.1 nTPM
- parathyroid gland: 0.1 nTPM
- retina: 0.1 nTPM
Single-cell type
- pituitary stem cells: 0.3 nCPM
- hepatocytes: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- non-classical monocyte: 1.5 nTPM
- neutrophil: 1.4 nTPM
- intermediate monocyte: 1.2 nTPM
- myeloid DC: 1.1 nTPM
- basophil: 1 nTPM
- eosinophil: 0.9 nTPM
Brain region
- choroid plexus: 18 nTPM
- cerebral cortex: 3.1 nTPM
- basal ganglia: 2.4 nTPM
- white matter: 2.1 nTPM
- amygdala: 2 nTPM
- thalamus: 1.9 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GNG5B as an antibody target. Whether an autoantibody or antibody against GNG5B could matter depends on whether native GNG5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GNG5B is annotated at the cell surface, where native GNG5B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GNG5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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