Seroatlas · Human Serome Atlas

GNG3

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Also known as: GBG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63215
Gene: GNG3
Ensembl: ENSG00000162188
Chromosome: 11
Canonical length: 75 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

75 residues, UniProt reviewed canonical sequence.

>P63215|GNG3
     1  MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC EDPLITPVPT
    61  SENPFREKKF FCALL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 465 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 465 nTPM
amygdala: 327 nTPM
hippocampal formation: 279 nTPM
cerebellum: 263 nTPM
hypothalamus: 254 nTPM
basal ganglia: 237 nTPM

Single-cell type

late spermatids: 248 nCPM
other brain neurons: 59 nCPM
brain excitatory neurons: 44 nCPM
brain inhibitory neurons: 42 nCPM
early spermatids: 26 nCPM
retinal amacrine cells: 25 nCPM

Immune cell

naive B-cell: 17 nTPM
memory B-cell: 17 nTPM
eosinophil: 0.5 nTPM
total PBMC: 0.4 nTPM
NK-cell: 0.3 nTPM
non-classical monocyte: 0.2 nTPM

Brain region

cerebral cortex: 496 nTPM
hypothalamus: 322 nTPM
white matter: 296 nTPM
pons: 263 nTPM
basal ganglia: 261 nTPM
hippocampal formation: 216 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNG3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 6 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.54
gnomAD missense Z: 1.16
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SCN8A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNG3 as an antibody target. Whether an autoantibody or antibody against GNG3 could matter depends on whether native GNG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNG3 is annotated at the cell surface, where native GNG3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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