Seroatlas · Human Serome Atlas

GNG14

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14

Also known as: GBG14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PPG7
Gene
GNG14
Ensembl
ENSG00000283980
Chromosome
19
Canonical length
107 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>A0A1W2PPG7|GNG14
     1  MSSKVAINSD IGQALWAVEQ LQMEAGIDQV KVRVGASAGG GKRWEHMGQG TGACLGLVWL
    61  NQLVCRCPKM AADLLKFCTE QAKNDPFLVG IPAATNSFKE KKPYAIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNG14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
0.9 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 0.9 nTPM
  • skin: 0.9 nTPM
  • testis: 0.7 nTPM
  • thyroid gland: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • bone marrow: 0.3 nTPM

Single-cell type

  • late spermatids: 6.2 nCPM
  • early spermatids: 0.6 nCPM
  • neutrophils: 0.2 nCPM
  • endometrial ciliated cells: 0.1 nCPM
  • epididymal efferent duct absorptive cells: 0.1 nCPM
  • epididymal principal cells: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 5.5 nTPM
  • basal ganglia: 5.1 nTPM
  • hippocampal formation: 4.8 nTPM
  • choroid plexus: 4 nTPM
  • amygdala: 3.9 nTPM
  • cerebellum: 3.9 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNG14 as an antibody target. Whether an autoantibody or antibody against GNG14 could matter depends on whether native GNG14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNG14 is annotated at the cell surface, where native GNG14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNG14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNG14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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