Seroatlas · Human Serome Atlas

GNG13

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Also known as: G(gamma)13, GBG13_HUMAN, h2-35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2W3
Gene: GNG13
Ensembl: ENSG00000127588
Chromosome: 16
Canonical length: 67 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

67 residues, UniProt reviewed canonical sequence.

>Q9P2W3|GNG13
     1  MEEWDVPQMK KEVESLKYQL AFQREMASKT IPELLKWIED GIPKDPFLNP DLMKNNPWVE
    61  KGKCTIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNG13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 58 nTPM
retina: 52 nTPM
cerebral cortex: 15 nTPM
spinal cord: 2.6 nTPM
amygdala: 2.4 nTPM
hypothalamus: 2.1 nTPM

Single-cell type

tuft cells: 265 nCPM
retinal bipolar cells: 166 nCPM
retinal pigment epithelial cells: 13 nCPM
respiratory ionocytes: 2.5 nCPM
bergmann glia: 2.3 nCPM
rod photoreceptor cells: 2.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 112 nTPM
thalamus: 58 nTPM
cerebral cortex: 15 nTPM
white matter: 14 nTPM
midbrain: 14 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G-protein beta-subunit binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

G-protein, gamma subunit
G-protein, gamma subunit-like domain
G-protein gamma-like domain superfamily
GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNG13 as an antibody target. Whether an autoantibody or antibody against GNG13 could matter depends on whether native GNG13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNG13 is annotated at the cell surface, where native GNG13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNG13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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