GNG11
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Also known as: GBG11_HUMAN, GNGT11
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P61952
- Gene
- GNG11
- Ensembl
- ENSG00000127920
- Chromosome
- 7
- Canonical length
- 73 aa
- Protein class
- Predicted intracellular proteins, RAS pathway related proteins
OverviewNCBI Gene
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
73 residues, UniProt reviewed canonical sequence.
>P61952|GNG11
1 MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED
61 KNPFKEKGSC VISLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GNG11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 81 nTPM
Expression across tissuesHPA
Tissue
- placenta: 81 nTPM
- adipose tissue: 73 nTPM
- breast: 63 nTPM
- ovary: 55 nTPM
- heart muscle: 49 nTPM
- lung: 38 nTPM
Single-cell type
- platelets: 6,641 nCPM
- megakaryocytes: 1,477 nCPM
- lymphatic endothelial cells: 1,181 nCPM
- vascular endothelial cells: 840 nCPM
- epididymal efferent duct absorptive cells: 552 nCPM
- retinal pigment epithelial cells: 456 nCPM
Immune cell
- total PBMC: 50 nTPM
- basophil: 21 nTPM
- neutrophil: 9.8 nTPM
- plasmacytoid DC: 3.7 nTPM
- memory B-cell: 2.3 nTPM
- naive B-cell: 2 nTPM
Brain region
- thalamus: 8.1 nTPM
- pons: 6.4 nTPM
- spinal cord: 6 nTPM
- medulla oblongata: 5.6 nTPM
- white matter: 5.4 nTPM
- cerebellum: 5.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0.55
- gnomAD missense Z
- 0.55
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GNG11 as an antibody target. Whether an autoantibody or antibody against GNG11 could matter depends on whether native GNG11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GNG11 is annotated at the cell surface, where native GNG11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GNG11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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