Seroatlas · Human Serome Atlas

GNB1L

Guanine nucleotide-binding protein subunit beta-like protein 1

Also known as: GNB1L_HUMAN, GY2, WDR14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYB4
Gene
GNB1L
Ensembl
ENSG00000185838
Chromosome
22
Canonical length
327 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q9BYB4|GNB1L
     1  MTAPCPPPPP DPQFVLRGTQ SPVHALHFCE GAQAQGRPLL FSGSQSGLVH IWSLQTRRAV
    61  TTLDGHGGQC VTWLQTLPQG RQLLSQGRDL KLCLWDLAEG RSAVVDSVCL ESVGFCRSSI
   121  LAGGQPRWTL AVPGRGSDEV QILEMPSKTS VCALKPKADA KLGMPMCLRL WQADCSSRPL
   181  LLAGYEDGSV VLWDVSEQKV CSRIACHEEP VMDLDFDSQK ARGISGSAGK ALAVWSLDWQ
   241  QALQVRGTHE LTNPGIAEVT IRPDRKILAT AGWDHRIRVF HWRTMQPLAV LAFHSAAVQC
   301  VAFTADGLLA AGSKDQRISL WSLYPRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNB1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
5.6 nTPM

Expression across tissuesHPA

Tissue

  • skin: 5.6 nTPM
  • spleen: 5 nTPM
  • esophagus: 4.7 nTPM
  • cerebral cortex: 4.4 nTPM
  • cervix: 3.9 nTPM
  • duodenum: 3.9 nTPM

Single-cell type

  • early spermatids: 44 nCPM
  • endometrial luminal cells: 32 nCPM
  • esophageal basal cells: 25 nCPM
  • migrating cytotrophoblasts: 23 nCPM
  • basal keratinocytes: 22 nCPM
  • cytotrophoblasts: 21 nCPM

Immune cell

  • T-reg: 17 nTPM
  • eosinophil: 16 nTPM
  • plasmacytoid DC: 13 nTPM
  • gdT-cell: 13 nTPM
  • MAIT T-cell: 13 nTPM
  • memory CD4 T-cell: 13 nTPM

Brain region

  • cerebral cortex: 9.1 nTPM
  • hippocampal formation: 7 nTPM
  • basal ganglia: 6.4 nTPM
  • medulla oblongata: 6.3 nTPM
  • white matter: 6.1 nTPM
  • amygdala: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNB1L as an antibody target. Whether an autoantibody or antibody against GNB1L could matter depends on whether native GNB1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNB1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GNB1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNB1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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