Seroatlas · Human Serome Atlas

GMPR2

GMP reductase 2

Also known as: GMPR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2T1
Gene: GMPR2
Ensembl: ENSG00000100938
Chromosome: 14
Canonical length: 348 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q9P2T1|GMPR2
     1  MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT
    61  FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI
   121  PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI
   181  GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM
   241  LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD
   301  VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMPR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 90 nTPM
kidney: 75 nTPM
parathyroid gland: 64 nTPM
blood vessel: 60 nTPM
thyroid gland: 58 nTPM
spleen: 55 nTPM

Single-cell type

other brain neurons: 14 nCPM
oligodendrocytes: 13 nCPM
microglia: 12 nCPM
brain inhibitory neurons: 10 nCPM
astrocytes: 10 nCPM
bergmann glia: 10 nCPM

Immune cell

neutrophil: 56 nTPM
myeloid DC: 36 nTPM
classical monocyte: 34 nTPM
T-reg: 31 nTPM
non-classical monocyte: 28 nTPM
intermediate monocyte: 27 nTPM

Brain region

choroid plexus: 20 nTPM
pons: 17 nTPM
medulla oblongata: 17 nTPM
thalamus: 16 nTPM
white matter: 16 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GMPR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ERBB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMPR2 as an antibody target. Whether an autoantibody or antibody against GMPR2 could matter depends on whether native GMPR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMPR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GMPR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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