GMPR
GMP reductase 1
Also known as: GMPR1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P36959
- Gene
- GMPR
- Ensembl
- ENSG00000137198
- Chromosome
- 6
- Canonical length
- 345 aa
- Protein class
- Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
Canonical amino-acid sequenceUniProt
345 residues, UniProt reviewed canonical sequence.
>P36959|GMPR
1 MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT
61 FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV
121 PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV
181 GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM
241 LGGMFSGHTE CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD
301 VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GMPR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 344 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 344 nTPM
- tongue: 191 nTPM
- heart muscle: 97 nTPM
- choroid plexus: 75 nTPM
- midbrain: 62 nTPM
- prostate: 59 nTPM
Single-cell type
- platelets: 763 nCPM
- differentiating spermatogonia: 548 nCPM
- retinal pigment epithelial cells: 358 nCPM
- melanocytes: 356 nCPM
- undifferentiated spermatogonia: 353 nCPM
- erythrocyte progenitors: 295 nCPM
Immune cell
- total PBMC: 16 nTPM
- basophil: 15 nTPM
- NK-cell: 9.6 nTPM
- intermediate monocyte: 5 nTPM
- classical monocyte: 3.3 nTPM
- neutrophil: 3.3 nTPM
Brain region
- midbrain: 75 nTPM
- thalamus: 67 nTPM
- spinal cord: 62 nTPM
- hypothalamus: 59 nTPM
- medulla oblongata: 55 nTPM
- choroid plexus: 52 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.06
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.12
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GMPR as an antibody target. Whether an autoantibody or antibody against GMPR could matter depends on whether native GMPR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GMPR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GMPR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...